Department of Pulmonary and Critical Care Medicine, the Second Affiliated Hospital of Fujian Medical University, the Second Clinical Medical College of Fujian Medical University, Center of Respiratory Medicine of Fujian Province, Quanzhou,
Department of Central Laboratory, the Second Affiliated Hospital of Fujian Medical University, the Second Clinical Medical College of Fujian Medical University, Quanzhou, China.
Respiration. 2019;97(3):273-276. doi: 10.1159/000493757. Epub 2018 Oct 26.
Closure of bronchopleural fistula remains a difficult challenge for clinicians. Although several therapeutic approaches have been proposed, the clinical results are commonly unsatisfactory. Previous reports have indicated that autologous mesenchymal stem cells (MSCs) are useful for aiding treatment of bronchopleural fistula. We report here the use of umbilical cord MSCs to effect the successful closure of a bronchopleural fistula (5 mm) in a 33-year-old woman 6 months after a lobectomy. A review of the relevant literature is included. The use of MSCs may be a promising therapeutic method for the closure of bronchopleural fistula. Randomized controlled trials with larger samples are required.
支气管胸膜瘘的闭合仍然是临床医生面临的一个难题。尽管已经提出了几种治疗方法，但临床效果通常并不令人满意。既往研究表明，自体间充质干细胞（MSCs）有助于治疗支气管胸膜瘘。我们在此报告一例 33 岁女性患者，在肺叶切除术后 6 个月时发生 5mm 支气管胸膜瘘，使用脐带 MSCs 成功闭合瘘口。本文还对相关文献进行了回顾。MSCs 的使用可能是一种有前途的支气管胸膜瘘闭合治疗方法。需要进行更大样本量的随机对照试验。
