Igarashi Haruki, Kokubun Norito, Funakoshi Kei, Sakurai Shintaro, Hirata Koichi
Department of Neurology, Dokkyo Medical University.
Department of Endocrinology and Metabolism, Dokkyo Medical University.
Rinsho Shinkeigaku. 2018 Nov 28;58(11):668-672. doi: 10.5692/clinicalneurol.cn-001192. Epub 2018 Oct 27.
A 56-year-old man noted sudden onset of headache, fever, right pupil-spared oculomotor nerve palsy and consciousness disturbance. Swelling of pituitary with T high intensity on brain MRI suggested the diagnosis of pituitary apoplexy. Considering significant decrease of pituitary anterior lobe hormone and central diabetes insipidus, high dose of hydrocortisone was administered. Eight days after onset, consciousness level and headache improved. On day 30, brain MRI revealed the reduction of mass size, and on day 46, photophobia and double vision disappeared. Following the rapid response to steroid and disappearance of pituitary lesion, pituitary apoplexy was probably caused by panhypophisitis. Thin-slice brain MRI confirmed the compression of oculomotor nerve at inlet zone of cavernous sinus, suggesting the mechanism of oculomotor palsy was perfusion impairment of feeding artery.
一名56岁男性突然出现头痛、发热、右侧动眼神经麻痹(瞳孔未受累)及意识障碍。脑部磁共振成像(MRI)显示垂体肿胀,T加权像呈高信号,提示垂体卒中诊断。鉴于垂体前叶激素显著减少及中枢性尿崩症,给予大剂量氢化可的松治疗。发病8天后,意识水平及头痛症状改善。第30天,脑部MRI显示肿块大小缩小,第46天,畏光及复视消失。鉴于对类固醇治疗反应迅速且垂体病变消失,垂体卒中可能由全垂体炎引起。脑部薄层MRI证实海绵窦入口区动眼神经受压,提示动眼神经麻痹的机制为供血动脉灌注受损。