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Commentary: Antidepressive effects of targeting ELK-1 signal transduction.评论：靶向ELK-1信号转导的抗抑郁作用
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2
The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo.丝裂原活化蛋白激酶/细胞外信号调节激酶级联反应作用于Elk-1和环磷酸腺苷反应元件结合蛋白，以在体内控制齿状回中长时程增强依赖的基因表达。
J Neurosci. 2000 Jun 15;20(12):4563-72. doi: 10.1523/JNEUROSCI.20-12-04563.2000.
3
Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress.慢性不可预测轻度应激诱导的抑郁大鼠行为、齿状回神经发生及海马miR-124表达的动态变化
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Promoting neurogenesis in hippocampal dentate gyrus of chronic unpredictable stress-induced depressive-like rats with paeoniflorin.芍药苷促进慢性不可预测应激诱导的抑郁样大鼠海马齿状回神经发生
J Integr Neurosci. 2019 Mar 30;18(1):43-49. doi: 10.31083/j.jin.2019.01.116.
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I.c.v. administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation.脑室内注射食欲素-A通过海马体细胞增殖诱导出抗抑郁样效应。
Neuroscience. 2008 Dec 10;157(4):720-32. doi: 10.1016/j.neuroscience.2008.09.042. Epub 2008 Oct 1.
6
Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus.海马神经发生通过抑制腹侧齿状回赋予应激弹性。
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7
Chronic high corticosterone reduces neurogenesis in the dentate gyrus of adult male and female rats.慢性高皮质酮可减少成年雄性和雌性大鼠齿状回的神经发生。
Neuroscience. 2010 Jul 14;168(3):680-90. doi: 10.1016/j.neuroscience.2010.04.023. Epub 2010 Apr 18.
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Presence of conspecifics and their odor-impregnated objects reverse stress-decreased neurogenesis in mouse dentate gyrus.同种动物的存在及其带有气味的物体逆转了小鼠齿状回中应激引起的神经发生减少。
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Differential effects of acute and chronic nicotine on Elk-1 in rat hippocampus.急性和慢性尼古丁对大鼠海马中Elk-1的不同影响。
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Androgens increase survival of adult-born neurons in the dentate gyrus by an androgen receptor-dependent mechanism in male rats.雄激素通过雄激素受体依赖机制增加雄性大鼠齿状回内成年神经元的存活。
Endocrinology. 2013 Sep;154(9):3294-304. doi: 10.1210/en.2013-1129. Epub 2013 Jun 19.

本文引用的文献

1
Antidepressive effects of targeting ELK-1 signal transduction.靶向 Elk-1 信号转导的抗抑郁作用。
Nat Med. 2018 May;24(5):591-597. doi: 10.1038/s41591-018-0011-0. Epub 2018 May 7.
2
Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3β signaling pathway.海马体中SIRT6的上调通过阻断Akt/GSK3β信号通路诱导大鼠出现抑郁样行为。
Behav Brain Res. 2017 Apr 14;323:38-46. doi: 10.1016/j.bbr.2017.01.035. Epub 2017 Jan 24.
3
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.组蛋白去乙酰化酶SIRT6在多发性骨髓瘤细胞DNA损伤反应中作用的证据。
Blood. 2016 Mar 3;127(9):1138-50. doi: 10.1182/blood-2015-06-649970. Epub 2015 Dec 16.
4
Effect of chronic stress on short and long-term plasticity in dentate gyrus; study of recovery and adaptation.慢性应激对齿状回短期和长期可塑性的影响；恢复与适应的研究。
Neuroscience. 2014 Nov 7;280:121-9. doi: 10.1016/j.neuroscience.2014.09.005. Epub 2014 Sep 16.
5
The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein.F -box 蛋白 FBXO25 促进 ELK-1 蛋白的蛋白酶体依赖性降解。
J Biol Chem. 2013 Sep 27;288(39):28152-62. doi: 10.1074/jbc.M113.504308. Epub 2013 Aug 12.
6
Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction.单体蛋白-α1-Ras Elk-1 信号转导至线粒体介导β-淀粉样蛋白诱导的突触功能障碍。
J Neurosci. 2013 Mar 20;33(12):5367-74. doi: 10.1523/JNEUROSCI.2641-12.2013.
7
Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode.在重度抑郁发作期间，应答者和不应答者患者表现出不同的外周转录特征。
Transl Psychiatry. 2012 Nov 13;2(11):e185. doi: 10.1038/tp.2012.112.
8
Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents.抑郁症病理生理学和治疗的信号通路：快速作用药物的新机制。
Trends Neurosci. 2012 Jan;35(1):47-56. doi: 10.1016/j.tins.2011.11.004.
9
Long-lasting behavioral responses to stress involve a direct interaction of glucocorticoid receptors with ERK1/2-MSK1-Elk-1 signaling.长期的应激行为反应涉及糖皮质激素受体与 ERK1/2-MSK1-Elk-1 信号的直接相互作用。
Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13806-11. doi: 10.1073/pnas.1104383108. Epub 2011 Aug 1.
10
Elk-1 a transcription factor with multiple facets in the brain.Elk-1：一种在大脑中具有多方面作用的转录因子。
Front Neurosci. 2011 Mar 16;5:35. doi: 10.3389/fnins.2011.00035. eCollection 2011.

Commentary: Antidepressive effects of targeting ELK-1 signal transduction.

作者信息

Cho Chang-Hoon

机构信息

College of Health Science, Korea University, Seoul, South Korea.

出版信息

Front Mol Neurosci. 2018 Oct 12;11:384. doi: 10.3389/fnmol.2018.00384. eCollection 2018.

DOI:10.3389/fnmol.2018.00384
PMID:30369870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6194192/
Abstract
摘要