Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Department of Orthopaedic Surgery and Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
J Cell Physiol. 2019 Jun;234(6):8233-8240. doi: 10.1002/jcp.27649. Epub 2018 Oct 28.
Metastatic dissemination represents the final stage of tumor progression as well as the principal cause of cancer-associated deaths. Calpains are a conserved family of calcium-dependent cysteine proteinases with ubiquitous or tissue-specific expression. Accumulating evidence indicates a central role for calpains in tumor migration and invasion via participating in several key processes, including focal adhesion dynamics, cytoskeletal remodeling, epithelial-to-mesenchymal transition, and apoptosis. Activated after the increased intracellular calcium concentration ( ) induced by membrane channels and extracellular or intracellular stimuli, calpains induce the limited cleavage or functional modulation of various substrates that serve as metastatic mediators. This review covers established literature to summarize the mechanisms and underlying signaling pathways of calpains in cancer metastasis, making calpains attractive targets for aggressive tumor therapies.
转移扩散代表肿瘤进展的最后阶段，也是癌症相关死亡的主要原因。钙蛋白酶是一个保守的家族，是钙依赖性半胱氨酸蛋白酶，具有广泛或组织特异性表达。越来越多的证据表明，钙蛋白酶在肿瘤迁移和侵袭中起着核心作用，通过参与几个关键过程，包括粘着斑动力学、细胞骨架重塑、上皮间质转化和细胞凋亡。钙蛋白酶在膜通道和细胞外或细胞内刺激引起的细胞内钙离子浓度增加（）后被激活，诱导作为转移介质的各种底物的有限切割或功能调节。这篇综述涵盖了已建立的文献，总结了钙蛋白酶在癌症转移中的机制和潜在信号通路，使钙蛋白酶成为侵袭性肿瘤治疗的有吸引力的靶点。
