Al-Hakeim Hussein Kadhem, Alhillawi Zainab Hussein
a Department of Chemistry , College of Science, University of Kufa , Najaf , Iraq.
Growth Factors. 2018 Aug;36(3-4):178-185. doi: 10.1080/08977194.2018.1520707. Epub 2018 Oct 30.
Bone disorders and disturbed calcium (Ca) homeostasis are common disorders in β-thalassaemia major (β-TM). In the present study, two bone related markers are studied in β-TM patients with negative C-reactive protein for the first time; fibroblast growth factor receptor 2 (FGFR2) and CAPS protein. Another goal is to estimate the correlation between the recent parameters and bone biomaterials as a function of iron status parameters in β-TM patients. The results revealed that, in patients with β-TM serum FGFR2, CAPS, alkaline phosphatase (ALP) and Mg significantly increased while serum Ca levels were low as compared with controls. Ca status is correlated with iron overload in β-TM. A significant correlation was present between CAPS and FGFR2. In conclusion, FGFR2 and CAPS associated with Ca status and subsequent bone disturbances in β-TM patients. Their level can be predicted from the equation: CAPS =0.001ALP +0.48FGFR2-1.26Ca - 3.95Pi +12.76 with acceptable applicability.
骨骼疾病和钙（Ca）稳态紊乱是重型β地中海贫血（β-TM）中的常见病症。在本研究中，首次在C反应蛋白阴性的β-TM患者中研究了两种骨相关标志物；成纤维细胞生长因子受体2（FGFR2）和CAPS蛋白。另一个目标是评估β-TM患者近期参数与骨生物材料之间的相关性，作为铁状态参数的函数。结果显示，与对照组相比，β-TM患者血清FGFR2、CAPS、碱性磷酸酶（ALP）和镁显著升高，而血清钙水平较低。β-TM患者的钙状态与铁过载相关。CAPS与FGFR2之间存在显著相关性。总之，FGFR2和CAPS与β-TM患者的钙状态及随后的骨骼紊乱有关。它们的水平可通过以下方程预测：CAPS =0.001ALP +0.48FGFR2-1.26Ca - 3.95Pi +12.76，具有可接受的适用性。
