Carnesecchi Giulia, Lobello Raffaele, Liggieri Laura, Palmero Candida, Pescetto Luisa, Morelli Patrizia, Castagnola Elio, Bandettini Roberto
a Clinical Pathology Laboratory and Microbiology Unit , IRCCS Istituto Giannina Gaslini, Children's Hospital , Genova , Italy.
b Infectious Diseases Unit, IRCCS Istituto Giannina Gaslini, Children's Hospital , Genova , Italy.
J Chemother. 2018 Oct-Dec;30(6-8):338-341. doi: 10.1080/1120009X.2018.1522473. Epub 2018 Oct 30.
Minimal inhibitory concentrations (MIC, mg/l) of ceftaroline and ceftobiprole were evaluated over 70 methicillin-resistant Staphylococcus aureus (MRSA) strains with vancomycin MIC ≥1 isolated in a paediatric hospital. The proportion of non-wild-type strains (MIC > epidemiological cut off) was 18% for ceftobiprole and 64% for ceftaroline. Only 1.4% of strains was resistant to ceftobiprole, and none to ceftaroline. These results are worrisome, since show the presence of non-negligible proportions of MRSA strains with high MIC values for ceftaroline and ceftobiprole in a setting where both drugs were never used.
在一家儿科医院分离出的70株耐甲氧西林金黄色葡萄球菌（MRSA）菌株中，对头孢洛林和头孢比普的最低抑菌浓度（MIC，mg/l）进行了评估，这些菌株的万古霉素MIC≥1。头孢比普的非野生型菌株比例（MIC＞流行病学临界值）为18%，头孢洛林为64%。仅1.4%的菌株对头孢比普耐药，对头孢洛林无耐药菌株。这些结果令人担忧，因为在从未使用过这两种药物的情况下，显示出对头孢洛林和头孢比普具有高MIC值的MRSA菌株比例不可忽视。
