Vijatov-Djuric Gordana, Doronjski Aleksandra, Mitic Igor, Brkic Snezana, Barisic Nenad
Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Department of Pediatrics, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia.
Arch Rheumatol. 2017 Apr 4;32(3):234-243. doi: 10.5606/ArchRheumatol.2017.6067. eCollection 2017 Sep.
This study aims to determine the serum levels of interleukin-17A (IL-17A) in children with juvenile idiopathic arthritis (JIA) and analyze the correlation between IL-17A values and disease activity, certain clinical features, and laboratory markers of inflammation.
The study included 30 children (7 boys, 23 girls; mean age 8.8±5.3 years; range 1 to 18 years), who had been diagnosed with JIA (18 children were diagnosed during the study period and 12 children were diagnosed before the start of the study) and had active disease during the study period. Control group included 30 healthy, age- and sex- matched children (9 boys, 21 girls; mean age 8.3±4.8 years; range 1 to 18 years). The enzyme-linked immunosorbent assay was used to assess the serum IL-17A levels of children with JIA in the active phase of the disease and control group. Clinical and laboratory features of the disease were evaluated for the children with JIA.
Serum levels of IL-17A in children with JIA were significantly higher in comparison to control group. In children with JIA who were prospectively monitored, statistically significantly decreased IL-17A level was recorded in the inactive phase of the disease. The incidence of arthritis of coxofemoral joints was significantly more common, and the mean levels of erythrocyte sedimentation rate and C-reactive protein were significantly higher in the group of children with JIA with detectable levels of IL-17A. Children with JIA and detectable levels of IL-17A had significantly higher values of Juvenile Arthritis Disease Activity Score-27 in comparison to children with JIA and non-detectable IL-17A.
Assessment of serum IL-17A levels in early phases of JIA gives an opportunity for early detection of children that have higher risk for worse functional outcome.
本研究旨在测定幼年特发性关节炎（JIA）患儿血清白细胞介素-17A（IL-17A）水平，并分析IL-17A值与疾病活动度、某些临床特征及炎症实验室指标之间的相关性。
本研究纳入30例儿童（7例男孩，23例女孩；平均年龄8.8±5.3岁；年龄范围1至18岁），这些儿童已被诊断为JIA（18例儿童在研究期间被诊断，12例儿童在研究开始前被诊断）且在研究期间疾病处于活动期。对照组包括30例年龄和性别匹配的健康儿童（9例男孩，21例女孩；平均年龄8.3±4.8岁；年龄范围1至18岁）。采用酶联免疫吸附测定法评估疾病活动期JIA患儿及对照组儿童的血清IL-17A水平。对JIA患儿的疾病临床和实验室特征进行评估。
与对照组相比，JIA患儿血清IL-17A水平显著更高。在接受前瞻性监测的JIA患儿中，疾病非活动期记录到IL-17A水平在统计学上显著降低。在IL-17A可检测水平的JIA患儿组中，髋膝关节关节炎的发生率显著更常见，红细胞沉降率和C反应蛋白的平均水平显著更高。与IL-17A不可检测的JIA患儿相比，IL-17A可检测水平的JIA患儿的幼年关节炎疾病活动评分-27值显著更高。
在JIA早期评估血清IL-17A水平为早期发现功能预后较差风险较高的儿童提供了机会。
