Gökçen Neslihan, Başaran Sibel, Benlidayi İlke Coşkun, Özdemir Çiğdem, Seydaoğlu Gülşah
Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Medical Faculty of Çukurova University, Adana, Turkey.
Department of Physical Medicine and Rehabilitation, Medical Faculty of Çukurova University, Adana, Turkey.
Arch Rheumatol. 2016 Dec 15;32(1):32-38. doi: 10.5606/ArchRheumatol.2017.5919. eCollection 2017 Mar.
This study aims to evaluate the relationship between biological markers and quadriceps muscle strength, the correlation of clinical variables with quadriceps muscle strength, and the results according to the radiological severity in patients with knee osteoarthritis.
A total of 152 patients (22 males, 130 females; mean age 57.3±7.5 years; range 40 to 70 years) with primary knee osteoarthritis were included in the study. We evaluated biological markers of C-telopeptide of type I collagen, C-telopeptide of type II collagen, leptin, and osteocalcin along with 25-hydroxy vitamin D. We measured quadriceps muscle strength both by manual muscle tester and computerized isokinetic dynamometer. We evaluated pain and functional status of the patients by visual analog scale and Western Ontario and McMaster Universities Osteoarthritis Index. We analyzed the correlation between biological markers and quadriceps muscle strength along with clinical variables. We classified the strength of correlations as no-very weak, weak-moderate, moderate-strong, and excellent.
Of the patients, 76.9% (n=117) were obese. Quadriceps muscle strength measures were significantly lower in females than that in males. There was no-very weak correlation between biological marker levels and quadriceps muscle strength. However, weak-moderate correlations were found between clinical variables (pain and Western Ontario and McMaster Universities Osteoarthritis Index scores) and quadriceps muscle strength measures.
Among the measured biological markers, none had any influence on quadriceps muscle strength in patients with knee osteoarthritis. However, pain and functional status of the patients might affect quadriceps muscle strength.
本研究旨在评估生物标志物与股四头肌力量之间的关系、临床变量与股四头肌力量的相关性，以及膝关节骨关节炎患者根据放射学严重程度的结果。
本研究纳入了152例原发性膝关节骨关节炎患者（男性22例，女性130例；平均年龄57.3±7.5岁；范围40至70岁）。我们评估了I型胶原C端肽、II型胶原C端肽、瘦素、骨钙素以及25-羟基维生素D的生物标志物。我们通过手动肌力测试仪和计算机化等速测力计测量股四头肌力量。我们通过视觉模拟量表以及西安大略和麦克马斯特大学骨关节炎指数评估患者的疼痛和功能状态。我们分析了生物标志物与股四头肌力量以及临床变量之间的相关性。我们将相关性强度分为无-非常弱、弱-中度、中度-强和极好。
患者中76.9%（n = 117）为肥胖患者。女性的股四头肌力量测量值显著低于男性。生物标志物水平与股四头肌力量之间存在无-非常弱的相关性。然而，临床变量（疼痛以及西安大略和麦克马斯特大学骨关节炎指数评分）与股四头肌力量测量值之间存在弱-中度相关性。
在所测量的生物标志物中，没有一种对膝关节骨关节炎患者的股四头肌力量有任何影响。然而，患者的疼痛和功能状态可能会影响股四头肌力量。
