Vural Seçil, Ertop Pelin, Ceyhan Koray, Şanli Hatice
Department of Dermatology and Venereology, Medical Faculty of Ankara University, Ankara, Turkey.
Department of Pathology, Medical Faculty of Ankara University, Ankara, Turkey.
Arch Rheumatol. 2017 Jan 13;32(1):71-75. doi: 10.5606/ArchRheumatol.2017.5952. eCollection 2017 Mar.
Idiopathic granulomatous mastitis (IGM) is an unusual benign inflammatory disease of breast. Breast cancer mimics IGM both radiologically and clinically. However, IGM is a benign disease and awareness of such an entity prevents unnecessary surgical procedures. Although its etiology is unknown, it may be an autoimmune disease. There are few patients reported in the literature presenting with reactive arthritis and/or erythema nodosum accompanying IGM of breast. Granulomatous mastitis should be considered as a possible underlying cause of arthritis and erythema nodosum. In this article, we report this interesting association of IGM as an underlying cause of arthritis and generalized erythema nodosum in a 32-year-old female patient. Comprehensive examination for granulomatous mastitis showed no apparent underlying cause. Indomethacin was beneficial in treatment of arthritis and erythema nodosum. Resistant IGM was responsive to colchicine treatment. Clinical management and therapeutic approach have been discussed in detail.
特发性肉芽肿性乳腺炎（IGM）是一种不常见的乳腺良性炎症性疾病。乳腺癌在影像学和临床上都可能与IGM相似。然而，IGM是一种良性疾病，认识到这一实体可避免不必要的外科手术。尽管其病因不明，但可能是一种自身免疫性疾病。文献中报道的伴有乳腺IGM的反应性关节炎和/或结节性红斑患者很少。肉芽肿性乳腺炎应被视为关节炎和结节性红斑的可能潜在病因。在本文中，我们报告了一名32岁女性患者中IGM作为关节炎和全身性结节性红斑潜在病因的这一有趣关联。对肉芽肿性乳腺炎的全面检查未发现明显的潜在病因。吲哚美辛对关节炎和结节性红斑的治疗有益。耐药的IGM对秋水仙碱治疗有反应。已详细讨论了临床管理和治疗方法。
