Department of Pathology, Radboud university medical centre, Nijmegen, the Netherlands.
Department of Radiotherapy, Radboud University Medical Centre, Nijmegen, the Netherlands.
Histopathology. 2019 May;74(6):809-816. doi: 10.1111/his.13781. Epub 2019 Feb 10.
Tumour deposits (TDs) are clusters of cancer cells in the soft tissue that are discontinuous from the primary tumour. In this review we are exploring their relevance for prognosis in patients with gastric cancer.
A literature search was performed to identify studies providing data on TDs and prognosis in gastric cancer patients. Eight papers were included in the meta-analysis, which was carried out in terms of risk ratios (RR) and hazard ratios (HR) with 95% confidence interval (95% CI). Of 7445 patients, 1551 had TDs (20.9%). TDs were associated with a decreased overall survival (OS) in univariate (HR = 2.82, 95% CI = 1.9-4.3) and multivariate analyses (HR = 1.65, 95% CI = 1.3-2.1). TDs were also associated with known prognostic factors such as synchronous metastatic disease (RR = 9.5), invasion depth (RR = 1.8), lymph node metastasis (RR = 1.7), lymphatic invasion (RR = 1.7), vascular invasion (RR = 2.6) and poor differentiation (RR = 1.2).
We found a strong indication that TDs are independent predictors of prognosis in patients with gastric cancer; hence, TDs should be included in the staging of gastric cancers.
肿瘤沉积物 (TDs) 是指原发性肿瘤不连续的软组织中癌细胞的聚集。在本综述中，我们探讨了它们在胃癌患者预后中的相关性。
进行了文献检索，以确定提供胃癌患者 TDs 和预后数据的研究。共有 8 篇论文纳入荟萃分析，采用风险比 (RR) 和风险比 (HR) 及其 95%置信区间 (95%CI) 进行分析。在 7445 名患者中，有 1551 名患者存在 TDs（20.9%）。TDs 与单因素（HR = 2.82，95%CI = 1.9-4.3）和多因素分析（HR = 1.65，95%CI = 1.3-2.1）中的总生存期 (OS) 降低相关。TDs 还与已知的预后因素相关，例如同步转移性疾病 (RR = 9.5)、浸润深度 (RR = 1.8)、淋巴结转移 (RR = 1.7)、淋巴血管侵犯 (RR = 1.7) 和分化不良 (RR = 1.2)。
我们发现强有力的证据表明 TDs 是胃癌患者预后的独立预测因子；因此，TDs 应纳入胃癌分期。
