辅助性T细胞17（Th17）细胞衍生的白细胞介素-17A（IL-17A）通过信号转导和转录激活因子3（STAT3）/核因子κB（NF-κB）/Notch1信号通路促进非小细胞肺癌的肿瘤进展。
Th17 cell-derived IL-17A promoted tumor progression via STAT3/NF-κB/Notch1 signaling in non-small cell lung cancer.
作者信息
Wang Ruirui, Yang Li, Zhang Chaoqi, Wang Ruijie, Zhang Zhen, He Qianyi, Chen Xinfeng, Zhang Bin, Qin Zhihai, Wang Liping, Zhang Yi
机构信息
Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
出版信息
Oncoimmunology. 2018 Aug 23;7(11):e1461303. doi: 10.1080/2162402X.2018.1461303. eCollection 2018.
Non-small cell lung cancer (NSCLC) accounts for the majority of all lung cancer cases, which is the leading cause of cancer deaths worldwide. IL-17░A, the major effector cytokine derived from Th17 cells, is a key cytokine in tumor pathogenesis and modulates tumor progression. We aimed to identify whether IL-17░A derived from Th17 cells promotes the progression of NSCLC Here we found that the level of Th17 cells was increased in NSCLC and IL-17░A was mainly produced by CD4 cells (Th17 cells) in NSCLC. IL-17░A enhanced the migration, invasion and stemness of NSCLC via STAT3/NF-κB/Notch1 signaling. Blockade of this signaling inhibited the migration, invasion and stemness of NSCLC mediated by IL-17░A. Th17 cells in NSCLC were closely associated with poor prognosis of NSCLC patients. Our results indicated that Th17 cell-derived IL-17░A plays an important role in tumor progression of NSCLC via STAT3/NF-κB/Notch1 signaling. Therefore, therapeutic strategies against this pathway would be valuable to be developed for NSCLC treatment.
非小细胞肺癌（NSCLC）占所有肺癌病例的大多数，是全球癌症死亡的主要原因。白细胞介素-17A（IL-17A）是Th17细胞产生的主要效应细胞因子，是肿瘤发病机制中的关键细胞因子，可调节肿瘤进展。我们旨在确定Th17细胞来源的IL-17A是否促进NSCLC的进展。在此我们发现，NSCLC中Th17细胞水平升高，且IL-17A主要由NSCLC中的CD4细胞（Th17细胞）产生。IL-17A通过信号转导和转录激活因子3（STAT3）/核因子κB（NF-κB）/Notch1信号通路增强NSCLC的迁移、侵袭和干性。阻断该信号通路可抑制IL-17A介导的NSCLC的迁移、侵袭和干性。NSCLC中的Th17细胞与NSCLC患者的不良预后密切相关。我们的结果表明，Th17细胞来源的IL-17A通过STAT3/NF-κB/Notch1信号通路在NSCLC的肿瘤进展中起重要作用。因此，针对该通路开发治疗策略对NSCLC治疗具有重要价值。
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