Okuno Y, Okamoto Y, Yamada A, Baba K, Yabuuchi H
Vaccine. 1987 Jun;5(2):128-32. doi: 10.1016/0264-410x(87)90059-4.
Inactivated Japanese encephalitis (JE) vaccine was given to healthy children and their neutralizing antibody titres against nine JE virus strains were measured. After two shots of the vaccine in the first year, most of the children showed seroconversion, but their neutralizing antibody titres were not high, and one year after vaccination their titres had decreased to low levels. However, a booster dose of vaccine in the second year had a marked effect on the antibody response. The neutralizing antibodies induced by the vaccine reacted to almost the same extent with nine different JE virus strains, though significantly higher titres against the Nakayama strain, the vaccine strain, were observed after vaccination in the second year.
对健康儿童接种了灭活日本脑炎（乙脑）疫苗，并检测了他们针对9种乙脑病毒株的中和抗体滴度。在第一年接种两剂疫苗后，大多数儿童出现血清转化，但他们的中和抗体滴度不高，且在接种疫苗一年后其滴度已降至低水平。然而，第二年接种一剂加强疫苗对抗体反应有显著影响。该疫苗诱导的中和抗体对9种不同的乙脑病毒株反应程度几乎相同，不过在第二年接种疫苗后，针对疫苗株中山株的抗体滴度明显更高。
