Holmes F A, Glass J P, Ewer M S, Terjanian T, Tetu B
Am J Med. 1987 Jun;82(6):1238-42. doi: 10.1016/0002-9343(87)90232-4.
Tumors involving the carotid sinus and glossopharyngeal nerve may produce syncope due to bradycardia and hypotension. Carotid sinus syncope unrelated to cancer is usually caused by bradycardia and responds to control of the heart rate. When neoplastic disease involves the carotid sinus, vasodepressor hypotension, with or without bradycardia, is more common. Control of the heart rate alone is not effective. Although this syndrome is not common, it is probably not recognized in milder forms. Most patients in whom this syndrome develops have cancer of the head and neck. A patient with breast carcinoma metastatic to the neck and carotid sinus is described in whom syncope with hypotension and bradycardia developed. Although a temporary cardiac pacemaker controlled bradycardia, severe hypotensive episodes recurred despite treatment with anticholinergic and sympathomimetic drugs. The pathophysiology and therapy of this syndrome in patients with cancer are reviewed.
累及颈动脉窦和舌咽神经的肿瘤可能因心动过缓和低血压而导致晕厥。与癌症无关的颈动脉窦晕厥通常由心动过缓引起，可通过控制心率来应对。当肿瘤性疾病累及颈动脉窦时，血管减压性低血压（伴或不伴有心动过缓）更为常见。仅控制心率无效。尽管这种综合征并不常见，但较轻的形式可能未被识别。发生这种综合征的大多数患者患有头颈部癌症。本文描述了一名乳腺癌转移至颈部和颈动脉窦的患者，该患者出现了伴有低血压和心动过缓的晕厥。尽管临时心脏起搏器控制了心动过缓，但尽管使用了抗胆碱能药物和拟交感神经药物治疗，严重的低血压发作仍反复出现。本文对癌症患者中该综合征的病理生理学和治疗进行了综述。
