Nobori Chihoko, Uchima Yasutake, Aomatsu Naoki, Okada Takuma, Miyamoto Hironari, Kurihara Shigeaki, Wang En, Hirakawa Toshiki, Iwauchi Takehiko, Morimoto Junya, Yamagata Shigehito, Nakazawa Kazunori, Takeuchi Kazuhiro
Dept. of Surgery, Fuchu Hospital.
Gan To Kagaku Ryoho. 2018 Oct;45(10):1457-1459.
A 47-year-old woman presented with a hard umbilical nodule that appeared red and was painful. A biopsy of the umbilical nodule revealed adenocarcinoma. As a result of general examinations, the patient was diagnosed with umbilical, hepatic, and ovarian metastases from transverse colon cancer. She was treated with S-1 and oxaliplatin(SOX)plus bevacizumab chemotherapy. After 4 courses of chemotherapy, CT revealed that the primary lesion and umbilical and hepatic metastases had reduced in size. We considered this to be a partial response and thus administered 4 additional courses of SOX plus bevacizumab chemotherapy. Finally, she remained well for 22 months and achieved relatively good prognosis. An umbilical metastasis from an internal malignancy is known as a Sister Mary Joseph's nodule, and it has very poor prognosis. Most studies show that the survival period from the time of diagnosis is within 1 year. However, our case suggests that novel anti-cancer drugs or molecular-targeted agents may improve survival.
一名47岁女性出现一个坚硬的脐部结节，该结节呈红色且有压痛。脐部结节活检显示为腺癌。经过全面检查，患者被诊断为横结肠癌伴脐部、肝脏和卵巢转移。她接受了S-1和奥沙利铂（SOX）联合贝伐单抗化疗。4个疗程化疗后，CT显示原发灶以及脐部和肝脏转移灶缩小。我们认为这属于部分缓解，因此又给予了4个疗程的SOX联合贝伐单抗化疗。最后，她病情稳定了22个月，预后相对较好。内部恶性肿瘤的脐部转移被称为玛丽·约瑟夫修女结节，其预后非常差。大多数研究表明，从诊断时起生存期在1年以内。然而，我们的病例提示新型抗癌药物或分子靶向药物可能改善生存。
