Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), José Antonio Novais 10, 28040, Madrid, Spain.
Food Funct. 2018 Nov 14;9(11):6010-6019. doi: 10.1039/c8fo01323c.
Grape polyphenols have shown a promising role in the modulation of metabolic syndrome (MetS), mostly in animal models. However, clinical studies are scarce and they usually only consider a fraction of polyphenols, ignoring the non-extractable polyphenols (high molecular weight compounds or associated with macromolecules such as dietary fibre). This study aimed at evaluating the effect of grape pomace, rich in both extractable and non-extractable polyphenols, on markers of MetS. Fifty subjects (22 women) aged 20-65 with at least two MetS factors were randomly assigned to the product (daily dose of 8 g of dried grape pomace) or to the control group in a 6 week crossover design with a 4 week wash-out. Samples were collected at the beginning and at the end of both periods; half of the participants were subjected to an oral glucose tolerance test at the beginning and the end of the supplementation period. Grape pomace supplementation significantly improved fasting insulinaemia (p < 0.01), without affecting other cardiometabolic risk parameters. A tendency towards an improvement in postprandial insulinaemia was observed, particularly in those subjects with higher fasting insulin levels. Therefore, supplementation with grape pomace may be a strategy for improving insulin sensitivity in subjects at high cardiometabolic risk.
葡萄多酚在调节代谢综合征（MetS）方面表现出有前景的作用，主要在动物模型中。然而，临床研究很少，而且它们通常只考虑多酚的一部分，忽略了非可提取的多酚（高分子量化合物或与膳食纤维等大分子结合的多酚）。本研究旨在评估富含可提取和非可提取多酚的葡萄渣对 MetS 标志物的影响。50 名年龄在 20-65 岁之间、至少有两个 MetS 因素的受试者被随机分配到产品组（每日 8 克干葡萄渣剂量）或对照组，采用 6 周交叉设计，洗脱期为 4 周。在两个时期的开始和结束时采集样本；一半的参与者在补充期的开始和结束时进行口服葡萄糖耐量试验。葡萄渣补充剂显著改善了空腹胰岛素血症（p < 0.01），而其他心血管代谢风险参数没有变化。观察到餐后胰岛素血症有改善的趋势，特别是在空腹胰岛素水平较高的受试者中。因此，补充葡萄渣可能是改善高心血管代谢风险受试者胰岛素敏感性的一种策略。
