Hypertension Center of Excellence, Hattiesburg Clinic, Hattiesburg, Mississippi, USA.
J Am Coll Nutr. 2010 Oct;29(5):469-75. doi: 10.1080/07315724.2010.10719883.
Muscadine grape seeds have high concentrations of polyphenolic compounds with antioxidant and other properties that would be expected to have favorable effects on endothelial function.
To evaluate the effect of muscadine grape seed supplementation on endothelial function and cardiovascular risk factors in subjects with increased cardiovascular risk.
In a randomized, double-blind, placebo-controlled crossover trial, 50 adults with coronary disease or ≥1 cardiac risk factor received muscadine grape seed supplementation (1300 mg daily) and placebo for 4 weeks each, with a 4-week washout. Resting brachial diameter and brachial flow-mediated dilation (FMD) and biomarkers of inflammation, lipid peroxidation, and antioxidant capacity were determined at the beginning and end of each period and compared in mixed linear models.
There was no evidence of improved FMD (% change) with muscadine grape seed (muscadine grape seed: pre 5.2% ± 0.3%, post 4.6% ± 0.3%, p = 0.06; placebo: pre 5.3% ± 0.4%, post 5.2% ± 0.4%, p = 0.82; p for muscadine grape seed vs. placebo = 0.25). However, there was a significant increase in baseline diameter (mm) with muscadine grape seed supplementation (muscadine grape seed: pre 4.05 ± 0.09, post 4.23 ± 0.10, p = 0.002; placebo: pre 4.12 ± 0.11, post 4.12 ± 0.10, p = 0.93; p for muscadine grape seed vs. placebo = 0.026). All other biomarkers were not significantly altered by muscadine grape seed supplementation.
Four weeks of muscadine grape seed supplementation in subjects with increased cardiovascular risk did not produce a statistically significant increase in brachial flow-mediated vasodilation or a significant change in other biomarkers of inflammation, lipid peroxidation, or antioxidant capacity. However, the muscadine grape seed supplement did result in a significant increase in resting brachial diameter. The clinical significance of the effect on resting diameter is not yet established. More research is warranted to fully characterize the vascular effects of this and other grape-derived nutritional supplements and to determine whether these vascular effects translate into important clinical benefits.
麝香葡萄种子含有高浓度的多酚化合物，具有抗氧化和其他特性，预计对内皮功能有有利影响。
评估麝香葡萄种子补充剂对心血管风险增加的受试者内皮功能和心血管危险因素的影响。
在一项随机、双盲、安慰剂对照的交叉试验中，50 名患有冠心病或≥1 个心脏危险因素的成年人分别接受麝香葡萄种子补充剂（每天 1300 毫克）和安慰剂治疗 4 周，洗脱期为 4 周。在每个时期的开始和结束时测量静息肱动脉直径和肱动脉血流介导的扩张（FMD）以及炎症、脂质过氧化和抗氧化能力的生物标志物，并在混合线性模型中进行比较。
麝香葡萄种子对 FMD（%变化）没有改善的证据（%变化）（麝香葡萄种子：预 5.2%±0.3%，后 4.6%±0.3%，p=0.06；安慰剂：预 5.3%±0.4%，后 5.2%±0.4%，p=0.82；p 麝香葡萄种子与安慰剂=0.25）。然而，麝香葡萄种子补充剂的基线直径（mm）显著增加（麝香葡萄种子：预 4.05±0.09，后 4.23±0.10，p=0.002；安慰剂：预 4.12±0.11，后 4.12±0.10，p=0.93；p 麝香葡萄种子与安慰剂=0.026）。麝香葡萄种子补充剂对其他所有生物标志物均无显著影响。
在心血管风险增加的受试者中，连续 4 周补充麝香葡萄种子并未使肱动脉血流介导的血管扩张有统计学意义的增加，也未使炎症、脂质过氧化或抗氧化能力的其他生物标志物发生显著变化。然而，麝香葡萄种子补充剂确实导致静息肱动脉直径显著增加。这种对静息直径的影响的临床意义尚不清楚。需要进一步的研究来充分描述这种和其他葡萄衍生的营养补充剂对血管的影响，并确定这些血管效应是否转化为重要的临床益处。
