Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.
BMC Genomics. 2018 Nov 1;19(1):787. doi: 10.1186/s12864-018-5183-y.
Macaca fascicularis (M. fascicularis) is a primate model organism that played important role in studying human health. It is vital to better understand the similarity and differences of gene regulation between M. fascicularis and human. Current comparative study of gene regulation between the two species are limited by low quality of gene annotation and lack of regulatory element data on M. fascicularis genome.
In this study, we improved the M. fascicularis gene annotation with 57 gene expression data from multiple tissues and, more importantly, a manual curation procedure. The new annotation enabled us to map gene expression and identify gene location more accurately.
Comparing with human gene expression data from the same cell types, we characterized the evolution of expression patterns of homologous genes.
猕猴（M. fascicularis）是一种灵长类动物模型生物，在研究人类健康方面发挥了重要作用。更好地理解猕猴和人类基因调控的相似性和差异性至关重要。目前，由于猕猴基因组上的基因注释质量低，以及缺乏调控元件数据，对这两个物种的基因调控进行比较研究受到限制。
在这项研究中，我们利用来自多个组织的 57 个基因表达数据以及更重要的手动注释程序改进了猕猴的基因注释。新的注释使我们能够更准确地映射基因表达并识别基因位置。
与来自相同细胞类型的人类基因表达数据相比，我们描述了同源基因表达模式的进化。
