在 S 期核中可视化组蛋白变体的动态变化。
Visualizing the dynamics of histone variants in the S-phase nucleus.
机构信息
Laboratory of Biology, School of Medicine, University of Patras, Patras, Greece.
Laboratory of Physiology, School of Medicine, University of Patras, Patras, Greece.
出版信息
Genome Biol. 2018 Oct 31;19(1):182. doi: 10.1186/s13059-018-1556-4.
Abstract
Histone variants constitute a fundamental feature of the epigenome. However, their dynamics during normal and challenged DNA replication and their distribution in the three-dimensional space of the nucleus remain poorly characterized. A recent study employed stochastic optical reconstruction microscopy (STORM) to obtain a high-resolution view of the spatial distribution of H3 histone variants in the nucleus and related this to the timing of DNA replication.
摘要
组蛋白变体是表观基因组的一个基本特征。然而，它们在正常和受挑战的 DNA 复制过程中的动态变化及其在核三维空间中的分布仍未得到很好的描述。最近的一项研究采用随机光学重建显微镜（STORM）获得了核内 H3 组蛋白变体空间分布的高分辨率视图，并将其与 DNA 复制的时间联系起来。
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