甲状腺素运载蛋白在调节肽神经保护生物学机制中的可能作用。

[POSSIBLE ROLE OF TRANSTHYRETIN IN THE BIOLOGICAL MECHANISM OF THE REGULATORY PEPTIDE NEUROPROTECTION.].

作者信息

Vyunova T V, Medvedeva E V, Andreeva L A, Dergunova L V, Limborska S A, Myasoedov N F

出版信息

Mol Gen Mikrobiol Virusol. 2016;34(3):104-109.

Abstract

The peptide preparation Semax has been effectively used for therapy of ischemic stroke. However, the mechanisms of its action are insufficiently understood and actively studied. The full-genome analysis of the transcriptome implemented in our recent work dem- onstrated that under conditions of focal ischemia of rat brain the Semax modified the profile of the transcription activity of many genes. In this case, the difference in the transcription levels of the gene encoding the protein transthyretin (Ttr) expression in rats under the pathological conditions of ischemia and in the presence of Semax was very high. High similarity between the effects of Ttr and coupled molecular systems with the Semax effects in ischemic stroke allowed us to suggest that the neuroprotection mechanisms of Semax (and, possibly, of other neuroprotection mechanisms of Semax) could be mediated by Ttr. In this review, we discussed the role of Ttr in CNS and its possible role in the neuroprotection mechanism of Semax.

摘要

肽制剂Semax已被有效地用于缺血性中风的治疗。然而，其作用机制尚未得到充分理解，仍在积极研究中。我们最近工作中实施的转录组全基因组分析表明，在大鼠脑局灶性缺血条件下，Semax改变了许多基因的转录活性谱。在这种情况下，在缺血病理条件下以及存在Semax时，大鼠中编码转甲状腺素蛋白（Ttr）表达的基因转录水平差异非常大。Ttr的作用与耦合分子系统在缺血性中风中的作用与Semax的作用高度相似，这使我们认为Semax的神经保护机制（以及Semax的其他神经保护机制）可能由Ttr介导。在这篇综述中，我们讨论了Ttr在中枢神经系统中的作用及其在Semax神经保护机制中的可能作用。