激肽酶活性在兔肾单位中的分布。

Distribution of kininase activity along the rabbit nephron.

作者信息

Omata K, Abe K, Yoshinaga K, Carretero O

出版信息

Clin Exp Hypertens A. 1987;9(2-3):469-72. doi: 10.3109/10641968709164214.

DOI:10.3109/10641968709164214

Abstract

The distribution of kininases along microdissected nephron segments was studied. Single nephrons from collagenase treated rabbit kidney were microdissected and divided into following 9 segments: glomerulus; early proximal tubule; middle proximal tubule; late proximal tubule; cortical thick ascending limb; distal convoluted tubule; connecting tubule; cortical collecting tubule; medullary collecting tubule. Kininase activities in these nephron segments were measured with or without kininase II inhibitor. Kininase II and other peptidases were mainly localized in glomeruli and whole part of the proximal tubules.

摘要

研究了激肽酶沿显微解剖的肾单位节段的分布情况。对经胶原酶处理的兔肾中的单个肾单位进行显微解剖，并将其分为以下9个节段：肾小球；近端小管起始段；近端小管中段；近端小管终段；皮质厚壁升支；远曲小管；连接小管；皮质集合小管；髓质集合小管。在有或没有激肽酶II抑制剂的情况下，测量这些肾单位节段中的激肽酶活性。激肽酶II和其他肽酶主要定位于肾小球和近端小管的整个部分。