血管紧张素I转换酶抑制剂长期治疗对自发性高血压大鼠循环心房钠尿肽的影响。

Effect of chronic treatment with angiotensin I converting enzyme inhibitors on circulating atrial natriuretic polypeptide in spontaneously hypertensive rats.

作者信息

Kohno M, Yasunari K, Matsuura T, Kanayama Y, Takaori K, Murakawa K, Takeda T

出版信息

Clin Exp Hypertens A. 1987;9(2-3):693-6. doi: 10.3109/10641968709164244.

DOI:10.3109/10641968709164244

Abstract

We have recently shown that circulating atrial natriuretic polypeptide (ANP) in adult spontaneously hypertensive rats (SHR) is higher than that in age-matched Wistar-Kyoto rats (WKY). The present experiment was designed to examine the possible effects of chronic treatment with angiotensin I converting enzyme inhibitors (ACEI) on plasma ANP levels in SHR. Captopril and enalapril lowered blood pressure and reduced relative ventricular weight in SHR but not to the level of WKY. Plasma ANP levels were decreased by captopril and enalapril compared with untreated SHR. These results suggest that the ANP release may be suppressed in ACEI-treated SHR compared with untreated SHR. We speculate that a reduction of cardiac overload by ACEI may in part explain the decline of circulating ANP.

摘要

我们最近发现，成年自发性高血压大鼠（SHR）循环中的心房利钠多肽（ANP）水平高于年龄匹配的Wistar-Kyoto大鼠（WKY）。本实验旨在研究血管紧张素I转换酶抑制剂（ACEI）长期治疗对SHR血浆ANP水平的可能影响。卡托普利和依那普利降低了SHR的血压并减轻了相对心室重量，但未降至WKY的水平。与未治疗的SHR相比，卡托普利和依那普利使血浆ANP水平降低。这些结果表明，与未治疗的SHR相比，ACEI治疗的SHR中ANP释放可能受到抑制。我们推测，ACEI减轻心脏负荷可能部分解释了循环ANP的下降。