Department of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Life Sci. 2018 Dec 1;214:176-183. doi: 10.1016/j.lfs.2018.10.062. Epub 2018 Oct 30.
The YAP and TAZ, as the downstream effectors of Hippo pathway, have emerged as important translational co-activators of a wide variety of biological processes. YAP/TAZ plays a crucial role in the lung development and physiology. Dysregulation of YAP/TAZ signaling pathway contributes to the development and progression of chronic lung diseases, including lung cancer, pulmonary fibrosis, pulmonary hypertension, COPD, asthma, and lung infection. Therefore, owing to its critical functions, delineation of the signaling mechanisms of YAP/TAZ in pathological conditions will shed light on developing strategies for its therapeutic targeting. Currently, the complex regulation of this pathway is under extensive investigation. In this review, we summarize and present recent findings of molecular mechanisms of YAP/TAZ in the lung physiological and pathological conditions, as well as the implications of YAP/TAZ for lung diseases treatment and regeneration.
YAP 和 TAZ 作为 Hippo 通路的下游效应物，已成为多种生物学过程的重要翻译共激活因子。YAP/TAZ 在肺发育和生理学中起着关键作用。YAP/TAZ 信号通路的失调导致慢性肺部疾病（包括肺癌、肺纤维化、肺动脉高压、COPD、哮喘和肺部感染）的发生和发展。因此，由于其关键功能，阐明 YAP/TAZ 在病理条件下的信号机制将为其治疗靶向提供思路。目前，该途径的复杂调控正在广泛研究中。在这篇综述中，我们总结和介绍了 YAP/TAZ 在肺生理和病理条件下的分子机制的最新发现，以及 YAP/TAZ 对肺部疾病治疗和再生的意义。
