Revet Alexis, Yrondi Antoine, Montastruc François
Centre hospitalier universitaire, service universitaire de psychiatrie de l'enfant et de l'adolescent, 31000 Toulouse, France.
Centre hospitalier universitaire, service de psychiatrie et psychologie médicale, 31000 Toulouse, France.
Presse Med. 2018 Oct;47(10):872-877. doi: 10.1016/j.lpm.2018.10.008. Epub 2018 Oct 29.
Due to pharmacologic tolerance and dependence, benzodiazepines and z-drugs have to be used over short duration of treatment. Three pharmacokinetic characteristics should be taken into account by the prescriber: the galenic form, the plasma half-life, and the presence of an active metabolite. The patient and the prescriber should talk about possible adverse events and treatment discontinuation before treatment initiation. Treatment duration should be as short as possible et should not be longer than recommended by the marketing authorization. Several benzodiazepine drugs should not be prescribed at the same time, because there is no advantage in terms of effectiveness and adverse events may occur.
由于药理学耐受性和依赖性,苯二氮䓬类药物和Z类药物必须在短疗程内使用。开处方者应考虑三个药代动力学特征:剂型、血浆半衰期和活性代谢物的存在。患者和开处方者应在治疗开始前讨论可能的不良事件和停药问题。治疗持续时间应尽可能短,且不应超过上市许可推荐的时间。几种苯二氮䓬类药物不应同时开具,因为在有效性方面没有优势,且可能会发生不良事件。