Szabo B, Hedler L, Lichtwald K, Starke K
Eur J Pharmacol. 1987 Apr 29;136(3):391-9. doi: 10.1016/0014-2999(87)90312-8.
ACTH 0.03-1 microgram/kg per min i.v. increased the noradrenaline spillover rate (the rate at which endogenous noradrenaline enters into plasma) and the plasma noradrenaline concentration in pithed rabbits with electrically stimulated sympathetic outflow. ACTH 0.1 and 1 microgram/kg per min decreased the mean arterial pressure (MAP). The effects of ACTH persisted in animals treated with propranolol. Corticosterone 10 micrograms/kg per min had no effect on the neurochemical and circulatory parameters. ACTH 0.03 and 1 microgram/kg per min increased plasma corticosterone and cortisol concentrations; the two doses of ACTH had approximately the same effect. The plasma corticosterone concentration reached after infusion of corticosterone 10 micrograms/kg per min was about twice that obtained after ACTH 0.03 or 1 microgram/kg per min. In a second series of experiments, a pressor dose of noradrenaline (1 or 2 micrograms/kg per min) was infused i.v. into pithed rabbits. ACTH 0.03 and 1 microgram/kg per min decreased blood pressure and increased heart rate in these animals. The results suggest that high doses of ACTH increase noradrenaline release by an action on postganglionic sympathetic neurons. The effect is probably not mediated through adrenal steroids. In addition, ACTH seems to decrease MAP and to increase heart rate through postsynaptic vascular and myocardial effects.
静脉注射促肾上腺皮质激素（ACTH），剂量为0.03 - 1微克/千克每分钟，可使去大脑兔在交感神经传出纤维受到电刺激时的去甲肾上腺素溢出率（内源性去甲肾上腺素进入血浆的速率）和血浆去甲肾上腺素浓度升高。ACTH剂量为0.1和1微克/千克每分钟时可使平均动脉压（MAP）降低。ACTH的这些作用在用普萘洛尔治疗的动物中仍然存在。皮质酮剂量为10微克/千克每分钟时，对神经化学和循环参数没有影响。ACTH剂量为0.03和1微克/千克每分钟时可使血浆皮质酮和皮质醇浓度升高；这两个剂量的ACTH作用大致相同。静脉注射皮质酮剂量为10微克/千克每分钟后达到的血浆皮质酮浓度约为ACTH剂量为0.03或1微克/千克每分钟后所获浓度的两倍。在第二组实验中，将升压剂量的去甲肾上腺素（1或2微克/千克每分钟）静脉注射到去大脑兔体内。ACTH剂量为0.03和1微克/千克每分钟时可使这些动物的血压降低、心率加快。结果表明，高剂量的ACTH通过作用于节后交感神经元增加去甲肾上腺素释放。这种作用可能不是通过肾上腺类固醇介导的。此外，ACTH似乎通过对突触后血管和心肌的作用降低MAP并增加心率。
