二丙诺啡对豚鼠回肠肌间神经丛中的阿片κ受体具有激动活性。
Diprenorphine has agonist activity at opioid kappa-receptors in the myenteric plexus of the guinea-pig ileum.
作者信息
Traynor J R, Corbett A D, Kosterlitz H W
出版信息
Eur J Pharmacol. 1987 May 7;137(1):85-9. doi: 10.1016/0014-2999(87)90185-3.
PMID:3038579
Abstract
The opioid agonist and antagonist activities of diprenorphine have been tested in four in vitro bioassay preparations. Diprenorphine is an antagonist at delta-receptors in the hamster vas deferens, at mu-receptors in the rat vas deferens and at kappa-receptors in the rabbit vas deferens. In the guinea-pig ileum it is an antagonist at mu-receptors and an agonist at kappa-receptors.
摘要
二丙诺啡的阿片样物质激动剂和拮抗剂活性已在四种体外生物测定制剂中进行了测试。二丙诺啡在仓鼠输精管的δ受体、大鼠输精管的μ受体和兔输精管的κ受体上是拮抗剂。在豚鼠回肠中，它在μ受体上是拮抗剂，在κ受体上是激动剂。
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