Gautam Swotantra, Joshi Brikha Raj, Adhikary Shailesh, Regmi Sudeep, Pradhan Anju
B P Koirala Institute of Health Sciences, Dharan, Nepal.
Department of Surgery, B P Koirala Institute of Health Sciences, Dharan, Nepal.
JNMA J Nepal Med Assoc. 2018 Jul-Aug;56(212):804-807. doi: 10.31729/jnma.3662.
Male breast carcinoma is a rare malignancy (<1% of all breast carcinomas, 0.2% of all male malignancies). Its common histopathological type is infiltrating carcinoma, not otherwise specified. Three male patients aged 56 (stage -IIIB), 64 (T4bN0M0) and 78 (T2N0MO) years presented with a breast lump within a year. Their hematological and biochemical parameters were within normal limits. Two of them had palpable regional lymph nodes. Male breast carcinoma occurs in older males as in our cases. Two cases showed infiltrating ductal carcinoma, not otherwise specified on histopathological evaluation, and one showed special type with apocrine differentiation. Their two-year follow-up was uneventful after modified radical mastectomy and chemotherapy. Male breast carcinoma is associated with risk factors different from and overlapping with female breast carcinoma. Male breast carcinoma differs from female breast carcinoma on clinical presentation, biological behaviour and prognosis. Male breast carcinoma as a separate clinical entity with its own biological behaviour is manageable by surgery and chemotherapy. Keywords: female breast carcinoma; infiltrating carcinoma; male breast carcinoma.
男性乳腺癌是一种罕见的恶性肿瘤（占所有乳腺癌的比例<1%，占所有男性恶性肿瘤的0.2%）。其常见的组织病理学类型为浸润性癌，未作其他特殊说明。三名男性患者，年龄分别为56岁（ⅢB期）、64岁（T4bN0M0）和78岁（T2N0M0），在一年内均出现乳腺肿块。他们的血液学和生化指标均在正常范围内。其中两人可触及区域淋巴结。男性乳腺癌如我们病例所示，多发生于老年男性。两例在组织病理学评估中显示为浸润性导管癌，未作其他特殊说明，一例显示为具有大汗腺分化的特殊类型。在改良根治性乳房切除术后并进行化疗，他们的两年随访情况良好。男性乳腺癌与女性乳腺癌的危险因素不同且有重叠。男性乳腺癌在临床表现、生物学行为和预后方面与女性乳腺癌不同。男性乳腺癌作为一个具有自身生物学行为的独立临床实体，可通过手术和化疗进行治疗。关键词：女性乳腺癌；浸润性癌；男性乳腺癌
