Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Center for Cognitive Brain Imaging, Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
J Affect Disord. 2019 Feb 15;245:126-129. doi: 10.1016/j.jad.2018.10.081. Epub 2018 Oct 5.
The extent to which observed differences in emotion processing and regulation neural circuitry in young adults with current suicidal ideation are paralleled by structural differences is unknown. We measured brain cortical thickness and gray and white matter volumes in 78 young adults aged 18-35: 35 with current suicidal ideation (SI) and 43 healthy controls (HC). The SI group, compared to HC, showed reduction in cortical thickness in the bilateral precentral gyri and diminished cortical volume in the left middle frontal gyrus. These regions are implicated in executive function, stress regulation, and emotion processing. We propose that these structural differences among the SI group could be contributing to suicidal thought patterns.
目前尚不清楚有自杀意念的年轻成年人在情绪处理和调节神经回路方面观察到的差异在多大程度上与结构差异平行。我们对 78 名年龄在 18 至 35 岁的年轻人进行了大脑皮质厚度以及灰质和白质体积的测量：35 名有当前自杀意念（SI），43 名健康对照（HC）。与 HC 相比，SI 组在双侧中央前回的皮质厚度减少，左额中回的皮质体积减少。这些区域与执行功能、应激调节和情绪处理有关。我们提出，SI 组的这些结构差异可能导致自杀思维模式。
