Chieng David, Paul Vince, Denman Russell
Department of Cardiology, Fiona Stanley Hospital, Perth, WA, Australia; Department of Cardiology, Royal Perth Hospital, Perth, WA, Australia.
Department of Cardiology, Fiona Stanley Hospital, Perth, WA, Australia.
Heart Lung Circ. 2019 Jan;28(1):65-75. doi: 10.1016/j.hlc.2018.09.011. Epub 2018 Oct 11.
Defibrillator technology for sudden cardiac death (SCD) prevention now includes the transvenous implantable cardiac defibrillator (ICD), subcutaneous ICD (S-ICD) and wearable cardioverter defibrillator (WCD). ICD use improves survival in patients who survived previous sudden cardiac arrest (SCA) due to ventricular tachycardia (VT)/ventricular fibrillation (VF), as well as in patients who experienced haemodynamically significant VT. It is also currently indicated for primary prevention in ischaemic/non-ischaemic cardiomyopathies, certain congenital heart disease conditions and inherited channelopathies. In this review article, we hope to present an updated review on ICD use for SCD prevention, with a focus on contemporary issues affecting ICD selection. These include: the role of primary prevention ICD in patients with non-ischaemic cardiomyopathy (NICM) in light of the 2016 DANISH (Danish Study to Assess the Efficacy of ICDs in Patients with Non-Ischemic Systolic Heart Failure on Mortality) trial; the role of defibrillator component (CRT-D) in patients receiving cardiac resynchronisation therapy (CRT-P); and the emerging role of cardiac magnetic resonance imaging (cMRI) in particular, the presence of late gadolinium enhancement (LGE), as an important SCD risk predictor. The current use of S-ICD and WCD, including clinical indications, evidence for efficacy and limitations, will also be discussed.
用于预防心源性猝死(SCD)的除颤器技术目前包括经静脉植入式心脏除颤器(ICD)、皮下植入式心脏除颤器(S-ICD)和可穿戴式心脏复律除颤器(WCD)。ICD的使用可提高因室性心动过速(VT)/室颤(VF)导致先前心脏骤停(SCA)幸存的患者以及发生血流动力学显著改变的VT患者的生存率。目前它还适用于缺血性/非缺血性心肌病、某些先天性心脏病和遗传性离子通道病的一级预防。在这篇综述文章中,我们希望对ICD用于预防SCD进行更新综述,重点关注影响ICD选择的当代问题。这些问题包括:鉴于2016年丹麦研究(丹麦评估ICD对非缺血性收缩性心力衰竭患者死亡率疗效的研究)试验,一级预防ICD在非缺血性心肌病(NICM)患者中的作用;除颤器组件(CRT-D)在接受心脏再同步治疗(CRT-P)患者中的作用;以及心脏磁共振成像(cMRI)尤其是钆延迟强化(LGE)作为重要SCD风险预测指标的新作用。还将讨论S-ICD和WCD的当前应用,包括临床适应证、疗效证据和局限性。