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冷冻消融:肺癌肾转移的一种潜在治疗选择?

Cryoablation: a potential treatment option for renal metastasis from lung cancer?

作者信息

Degn Stine, Davidsen Jesper Rømhild, Graumann Ole

机构信息

Radiology Department, Odense University Hospital, Odense, Denmark.

Respiratory Department, Odense University Hospital, Odense, Denmark.

出版信息

BMJ Case Rep. 2018 Nov 1;2018:bcr-2018-225841. doi: 10.1136/bcr-2018-225841.

DOI:10.1136/bcr-2018-225841
PMID:30389734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6214398/
Abstract

Cryoablation is successfully performed as a treatment for small renal cancers. The occurrence of a solitary renal metastasis from lung cancer is an uncommon finding entailing a limited knowledge on the choice of its optimal treatment. We present two patients diagnosed with non-small cell lung cancer, who were initially treated with curatively intended chemoradiotherapy. In the follow-up period, a non-symptomatic solitary renal metastasis was found in both patients. Both received CT-guided cryoablation of their renal metastases. One patient was successfully treated with no relapse, whereas the other patient received re-cryoablation due to development of a new renal metastasis. In both patients, no residual tumour was found at the 3 months' follow-up examination. Whether the minimally invasive procedure of cryoablation is a feasible treatment in the management of solitary renal metastases from lung cancer is still undetermined. The recurrence and incomplete treatment are concerns requiring further research.

摘要

冷冻消融术已成功用于治疗小肾癌。肺癌发生孤立性肾转移是一种罕见情况,对其最佳治疗选择的了解有限。我们报告了两名被诊断为非小细胞肺癌的患者,他们最初接受了旨在治愈的放化疗。在随访期间,两名患者均发现无症状的孤立性肾转移。两人均接受了CT引导下的肾转移瘤冷冻消融术。一名患者成功治愈且无复发,而另一名患者因出现新的肾转移而接受了再次冷冻消融术。在3个月的随访检查中,两名患者均未发现残留肿瘤。冷冻消融这种微创手术在肺癌孤立性肾转移的治疗中是否可行仍未确定。复发和治疗不彻底是需要进一步研究的问题。

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本文引用的文献

1
Solid renal masses in adults.成人实性肾肿块
Indian J Radiol Imaging. 2016 Oct-Dec;26(4):429-442. doi: 10.4103/0971-3026.195773.
2
Ablative Therapies for the Treatment of Small Renal Masses: a Review of Different Modalities and Outcomes.用于治疗小肾肿瘤的消融疗法:不同方式及结果的综述
Curr Urol Rep. 2016 Aug;17(8):59. doi: 10.1007/s11934-016-0611-5.
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Percutaneous Renal Cryoablation: Short-Axis Ice-Ball Margin as a Predictor of Outcome.经皮肾冷冻消融术:短轴冰球边缘作为预后预测指标
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Isolated Renal Metastasis from Non-Small-Cell Lung Cancer: Report of 2 Cases.非小细胞肺癌孤立性肾转移:2例报告
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Update on cryoablation for treatment of small renal mass: oncologic control, renal function preservation, and rate of complications.关于冷冻消融治疗小肾肿瘤的最新进展:肿瘤控制、肾功能保护和并发症发生率。
Curr Urol Rep. 2014 Apr;15(4):396. doi: 10.1007/s11934-014-0396-3.
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Isolated renal metastasis from squamous cell lung cancer.孤立性肾转移来自肺鳞状细胞癌。
Multidiscip Respir Med. 2013 Jan 16;8(1):2. doi: 10.1186/2049-6958-8-2.
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Non-small cell lung cancer with unsuspected distant metastasis to the kidney seen on PET/CT.PET/CT检查发现非小细胞肺癌伴有意外的肾远处转移。
Med Health R I. 2012 May;95(5):144-6.
8
Cryoablation: mechanism of action and devices.冷冻消融:作用机制与设备。
J Vasc Interv Radiol. 2010 Aug;21(8 Suppl):S187-91. doi: 10.1016/j.jvir.2009.12.403.
9
Percutaneous ablation for bone and soft tissue metastases--why cryoablation?经皮消融治疗骨与软组织转移瘤——为何选择冷冻消融?
Skeletal Radiol. 2009 Sep;38(9):835-9. doi: 10.1007/s00256-009-0736-4.
10
Persistent contrast enhancement several months after laparoscopic cryoablation of the small renal mass may not indicate recurrent tumor.肾小肿块腹腔镜冷冻消融术后数月持续的对比增强可能并不表明肿瘤复发。
J Endourol. 2008 Nov;22(11):2433-9. doi: 10.1089/end.2008.0261.