奈多罗米钠对变应原鼻激发试验的影响。

The effect of nedocromil sodium on nasal provocation with allergen.

作者信息

Corrado O J, Gomez E, Baldwin D L, Clague J E, Davies R J

出版信息

J Allergy Clin Immunol. 1987 Aug;80(2):218-22. doi: 10.1016/0091-6749(87)90132-1.

Abstract

We have investigated the effect of nedocromil sodium in preventing the symptoms of rhinitis occurring immediately after allergen provocation in 10 patients with allergic rhinitis. The study had a double-blind, placebo-controlled, crossover design. Nedocromil sodium (1% w/v) and placebo were administered intranasally from identical metered-dose inhalers 20 minutes before allergen provocation. Three variables were measured: nasal airway resistance, the production of secretion, and the number of sneezes. Nedocromil sodium was significantly more effective than placebo in preventing nasal obstruction (p less than 0.01), rhinorrhea (p less than 0.01), and sneezing (p less than 0.05), suggesting that this drug may be useful in the treatment of allergic rhinitis.

摘要

我们研究了奈多罗米钠对10例变应性鼻炎患者在变应原激发后立即预防鼻炎症状的效果。该研究采用双盲、安慰剂对照、交叉设计。在变应原激发前20分钟，通过相同的定量吸入器经鼻给予奈多罗米钠（1% w/v）和安慰剂。测量了三个变量：鼻气道阻力、分泌物产生量和喷嚏次数。在预防鼻塞（p<0.01）、鼻漏（p<0.01）和喷嚏（p<0.05）方面，奈多罗米钠比安慰剂显著更有效，提示该药可能对变应性鼻炎治疗有用。