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过敏性鼻炎的局部药物治疗:奈多罗米

Topical pharmacotherapy for allergic rhinitis: nedocromil.

作者信息

Mabry R L

机构信息

Department of Otolaryngology, University of Texas Southwestern Medical Center, Dallas 75235-9035.

出版信息

Am J Otolaryngol. 1993 Nov-Dec;14(6):379-81. doi: 10.1016/0196-0709(93)90110-s.

Abstract

Nedocromil sodium is a mast-cell stabilizer that prevents or ablates both the acute and late phases of the allergic response. It is an antiinflammatory agent that is not a steroid. It is more potent than the currently available mast-cell stabilizer, cromolyn, and maintenance therapy may be possible at less frequent intervals than the initially recommended regimen of 4 times daily. Nedocromil for pulmonary administration is currently available. The nasal form has undergone clinical trials but has not yet been released in the United States.

摘要

奈多罗米钠是一种肥大细胞稳定剂,可预防或消除过敏反应的急性期和晚期。它是一种非类固醇的抗炎药。它比目前可用的肥大细胞稳定剂色甘酸钠更有效,维持治疗的给药间隔可能比最初推荐的每日4次的方案更不频繁。目前有用于肺部给药的奈多罗米。鼻用剂型已进行临床试验,但尚未在美国上市。

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本文引用的文献

1
The effect of nedocromil sodium on nasal provocation with allergen.奈多罗米钠对变应原鼻激发试验的影响。
J Allergy Clin Immunol. 1987 Aug;80(2):218-22. doi: 10.1016/0091-6749(87)90132-1.
10
Allergen-induced changes in the nasal mucous membrane in seasonal allergic rhinitis: effect of nedocromil sodium.
J Allergy Clin Immunol. 1990 Jan;85(1 Pt 1):125-31. doi: 10.1016/0091-6749(90)90233-t.

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