肾素-血管紧张素系统对钠缺乏男性前臂和内脏区域肾上腺素能血管收缩反应的影响。

The influence of the renin-angiotensin system on adrenergic vasoconstrictor responses in the forearm and splanchnic region in sodium deplete man.

作者信息

Hesse B, Stadeager C, Rasmussen S, Henriksen O, Bonde-Petersen F

出版信息

J Hypertens Suppl. 1986 Dec;4(6):S402-5.

Abstract

In sodium deplete subjects forearm (FBF) and splanchnic (SBF) blood flows were measured at rest and during lower body negative pressure (LBNP) before and during angiotensin II (ANG II) blockade. Both FBF and SBF were reduced by LBNP. Forearm blood flow and forearm vascular resistance were unaffected by ANG II blockade (intra-arterial saralasin, n = 6; i.v. enalapril, n = 9) both at rest and during LBNP. In contrast, resting SBF increased and splanchnic vascular resistance decreased after i.v. enalapril (n = 10). The low resistance was completely unchanged during the following LBNP. It is concluded that acute ANG II blockade has no influence on the vascular resistance in the human forearm, but increases basal SBF in sodium depleted subjects and 'paralyses' the vasoconstrictor response to LBNP.

摘要

在钠缺乏受试者中，在血管紧张素II（ANG II）阻断之前和期间，于静息状态和下体负压（LBNP）期间测量前臂血流量（FBF）和内脏血流量（SBF）。LBNP使FBF和SBF均降低。在静息状态和LBNP期间，动脉内注射沙拉新（n = 6）或静脉注射依那普利（n = 9）进行ANG II阻断，均不影响前臂血流量和前臂血管阻力。相比之下，静脉注射依那普利后（n = 10），静息SBF增加，内脏血管阻力降低。在随后的LBNP期间，低阻力状态完全未改变。得出的结论是，急性ANG II阻断对人体前臂的血管阻力没有影响，但会增加钠缺乏受试者的基础SBF，并“麻痹”对LBNP的血管收缩反应。