普塔对沙塔普蒂阿卜拉克巴斯马对肺癌、白血病和前列腺癌细胞系的体外抗癌活性的影响。

Effect of Puta on in vitro anticancer activity of Shataputi AbhrakBhasma on lung, leukemia and prostate cancer cell lines.

作者信息

Tamhankar Yogesh L, Gharote Archana P

机构信息

Rasashastra and Bhaishajya Kalpana Dept., D.Y. Patil University, School of Ayurveda, Sector- 7, Nerul, Navi Mumbai, Maharashtra, 400706, India.

出版信息

J Ayurveda Integr Med. 2020 Apr-Jun;11(2):118-123. doi: 10.1016/j.jaim.2017.07.007. Epub 2018 Nov 2.

DOI:10.1016/j.jaim.2017.07.007

PMID:30391122

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7329716/

Abstract

BACKGROUND

Rasashastra needs to be upgraded using the technological advances, with regards to drug processing, development and therapeutics. The potential of Rasaaushadhis need to be explored by subjecting them against newer life threatening diseases like cancer where contemporary medicine has limitations. Abhrak Bhasma, one of the drugs of Rasashastra, has some peculiar attributes. According to classical Rasashastra texts, Shataputi Abhrak Bhasma is regarded as a Rasayan, whose efficacy is in direct proportion to the number of Putas. Thus increasing number of Putas not only has a significant effect on the physical, analytical aspects but also the therapeutic effect of the Abhrak Bhasma.

OBJECTIVES

To screen in vitro anticancer activity of Abhrak Bhasma at various stages of Putas (20, 50, 100). To evaluate and thus validate the principle from classical Rasashastra texts, which explains direct relation of number of Putas with therapeutic efficacy.

MATERIALS AND METHODS

Shataputi Abhrak Bhasma, at various stages of its preparation was subjected to in vitro anticancer activity on three different cancer cell lines (LungHOP62, LeukemiaU937, ProstateDU145) at Tata Memorial Centre- Advanced Centre for Treatment, Research Education in Cancer, Navi Mumbai. SRB assay was followed to evaluate the anti-proliferative activity.

RESULTS

It was found that Abhrak Bhasma shows concentration dependent positive in vitro anticancer activity on all three cell lines with highly significant activity on prostate cancer cell lines. Anticancer activity of Abhrak Bhasma is in the order 100 Puti > 50 Puti > 20 Puti. Shataputi Abhrak Bhasma had maximum activity on prostate cancer cell lines almost equivalent to positive control drug adriamycin.

CONCLUSION

The in vitro anticancer activity of Shataputi Abhrak Bhasma increases with increasing number of Putas, thus revalidating the direct relation between number of Putas and efficacy of the drug.

摘要

背景

随着药物加工、研发和治疗方面的技术进步，《吠陀医典》（Rasashastra）需要与时俱进。需要通过将“吠陀药物”（Rasaaushadhis）应用于当代医学存在局限性的新型威胁生命的疾病（如癌症）来探索其潜力。《吠陀医典》中的药物之一云母灰（Abhrak Bhasma）具有一些独特的特性。根据经典的《吠陀医典》文献，百次煅烧云母灰（Shataputi Abhrak Bhasma）被视为一种养生滋补药（Rasayan），其功效与煅烧次数成正比。因此，煅烧次数的增加不仅对物理、分析方面有显著影响，而且对云母灰的治疗效果也有显著影响。