Anticancer activity of (bioactive nanoparticles of zinc): A human pancreatic cancer cell line study.

BACKGROUND

Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer-related mortality. Efforts to improve cancer treatment through nanotechnology are at the developmental stage, and it will be gracious if the drug with anticancer property itself is a nanoparticle. is organomineral complexes which are bioactive nanoparticles. (incinerated processed zinc) is widely used in Ayurveda for various diseases, and there are evidence that ZnO nanoparticles are promising antitumor agent. However, no studies have been conducted on the effectiveness of in pancreatic cancer.

MATERIALS AND METHODS

Two types of test drugs, (PMY) and (JMY), were prepared as per the guidelines of pharmaceutics of Ayurveda. Particle size analyses of and Zeta potential study was carried out initially. Further human pancreatic cancer cell line (MIA PaCa-2) study was done using sulforhodamine B assay, keeping adriamycinas control. After 48 h of incubation, antiproliferative effects were assessed.

RESULTS

JMY and adriamycin showed dose-dependent growth inhibition of cancer cells. Both samples showed a cytostatic effect at this concentration.

CONCLUSION

The study leads to new avenues for cancer treatment by developing such unique and highly effective bioactive nano-sized therapeutic agent.