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（锌的生物活性纳米颗粒）的抗癌活性：一项人胰腺癌细胞系研究。

Anticancer activity of (bioactive nanoparticles of zinc): A human pancreatic cancer cell line study.

作者信息

Chandran Seetha, Patgiri Biswajyoti, Bedarkar Prashant, Mathat Dinesan

机构信息

Department of Rasasastra and Bhaishajya Kalpana, IPGT and RA, Gujarat Ayurved University, Jamnagar, Gujarat, India.

Department of Radiotherapy, Government Medical College, Kozhikode, Kerala, India.

出版信息

Ayu. 2019 Jan-Mar;40(1):58-63. doi: 10.4103/ayu.AYU_239_17.

DOI:10.4103/ayu.AYU_239_17
PMID:31831971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6891994/
Abstract

BACKGROUND

Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer-related mortality. Efforts to improve cancer treatment through nanotechnology are at the developmental stage, and it will be gracious if the drug with anticancer property itself is a nanoparticle. is organomineral complexes which are bioactive nanoparticles. (incinerated processed zinc) is widely used in Ayurveda for various diseases, and there are evidence that ZnO nanoparticles are promising antitumor agent. However, no studies have been conducted on the effectiveness of in pancreatic cancer.

MATERIALS AND METHODS

Two types of test drugs, (PMY) and (JMY), were prepared as per the guidelines of pharmaceutics of Ayurveda. Particle size analyses of and Zeta potential study was carried out initially. Further human pancreatic cancer cell line (MIA PaCa-2) study was done using sulforhodamine B assay, keeping adriamycinas control. After 48 h of incubation, antiproliferative effects were assessed.

RESULTS

JMY and adriamycin showed dose-dependent growth inhibition of cancer cells. Both samples showed a cytostatic effect at this concentration.

CONCLUSION

The study leads to new avenues for cancer treatment by developing such unique and highly effective bioactive nano-sized therapeutic agent.

摘要

背景

胰腺导管腺癌是癌症相关死亡的第四大主要原因。通过纳米技术改善癌症治疗的努力尚处于发展阶段，如果具有抗癌特性的药物本身就是纳米颗粒，那就太好了。有机矿物复合物是具有生物活性的纳米颗粒。煅烧锌在阿育吠陀医学中被广泛用于治疗各种疾病，并且有证据表明氧化锌纳米颗粒是有前景的抗肿瘤剂。然而，尚未对煅烧锌在胰腺癌中的有效性进行研究。

材料与方法

按照阿育吠陀医学药剂学指南制备了两种受试药物，即PMY和JMY。最初对JMY进行了粒度分析和zeta电位研究。以阿霉素为对照，使用磺酰罗丹明B试验对人胰腺癌细胞系（MIA PaCa-2）进行了进一步研究。孵育48小时后，评估抗增殖作用。

结果

JMY和阿霉素对癌细胞均表现出剂量依赖性生长抑制。在此浓度下，两种JMY样品均显示出细胞抑制作用。

结论

该研究通过开发这种独特且高效的生物活性纳米级治疗剂，为癌症治疗开辟了新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3a3/6891994/85eb30d272e4/AYU-40-58-g011.jpg
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