Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives.
作者信息
Wentland M P, Bailey D M, Alexander E J, Castaldi M J, Ferrari R A, Haubrich D R, Luttinger D A, Perrone M H
出版信息
J Med Chem. 1987 Aug;30(8):1482-9. doi: 10.1021/jm00391a034.
PMID:3039138
Abstract
A unique combination of alpha 2-adrenoreceptor antagonist and serotonin-selective reuptake inhibitory activities has been identified in a series of 2-substituted 4,5-dihydro-1H-imidazole derivatives. This combination of blocking activities has provided one of these derivatives, napamezole hydrochloride (2), with potential as an antidepressant. A discussion of the syntheses of these compounds includes a convenient method for the conversion of nitriles to imidazolines with ethylenediamine and trimethylaluminum.
摘要
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