The Task Force for Global Health, Decatur, Georgia; Centers for Disease Control and Prevention, Atlanta, Georgia.
The Task Force for Global Health, Decatur, Georgia.
Gastroenterology. 2019 Jan;156(2):297-310. doi: 10.1053/j.gastro.2018.10.048. Epub 2018 Nov 2.
Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause 1.3 million deaths annually. To prevent more than 7 million deaths by 2030, the World Health Organization set goals to eliminate HBV and HCV, defined as a 90% reduction in new infections and a 65% reduction in deaths, and prevent more than 7 million related deaths by 2030. Elimination of HBV and HCV is feasible because of characteristics of the viruses, reliable diagnostic tools, and available cost-effective or cost-saving interventions. Broad implementation of infant immunization against HBV, blood safety, and infection-control programs have greatly reduced the burden of HBV and HCV infections. To achieve elimination, priorities include implementation of HBV vaccine-based strategies to prevent perinatal transmission, safe injection practices and HCV treatment for persons who inject drugs, and testing and treatment for HBV- and HCV-infected persons. With sufficient capacity, HBV and HCV elimination programs can meet their goals.
乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)每年导致 130 万人死亡。为了在 2030 年之前防止 700 多万人死亡,世界卫生组织设定了消除 HBV 和 HCV 的目标,即新感染减少 90%,死亡减少 65%,并在 2030 年之前防止与 HBV 和 HCV 相关的 700 多万人死亡。由于病毒的特征、可靠的诊断工具和现有的具有成本效益或节省成本的干预措施,消除 HBV 和 HCV 是可行的。广泛实施婴儿乙型肝炎疫苗免疫接种、血液安全和感染控制计划,大大减轻了 HBV 和 HCV 感染的负担。为了实现消除目标,优先事项包括实施基于 HBV 疫苗的策略,以预防围产期传播、安全注射做法和对注射毒品者的 HCV 治疗,以及对 HBV 和 HCV 感染者的检测和治疗。只要有足够的能力,HBV 和 HCV 消除项目就可以实现其目标。