Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets.
作者信息
Uniken Venema Werna T, Voskuil Michiel D, Vila Arnau Vich, van der Vries Gerben, Jansen Bernadien H, Jabri Bana, Faber Klaas Nico, Dijkstra Gerard, Xavier Ramnik J, Wijmenga Cisca, Graham Daniel B, Weersma Rinse K, Festen Eleonora A
机构信息
Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
出版信息
Gastroenterology. 2019 Feb;156(3):812-815.e22. doi: 10.1053/j.gastro.2018.10.046. Epub 2018 Nov 2.
Abstract
摘要
相似文献
1
Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets.
Gastroenterology. 2019 Feb;156(3):812-815.e22. doi: 10.1053/j.gastro.2018.10.046. Epub 2018 Nov 2.
2
T-cell Composition in Ileal and Colonic Creeping Fat - Separating Ileal from Colonic Crohn's Disease.
J Crohns Colitis. 2019 Jan 1;13(1):79-91. doi: 10.1093/ecco-jcc/jjy146.
3
Colonic epithelial miR-31 associates with the development of Crohn's phenotypes.
JCI Insight. 2018 Oct 4;3(19):122788. doi: 10.1172/jci.insight.122788.
4
Profoundly Expanded T-cell Clones in the Inflamed and Uninflamed Intestine of Patients With Crohn's Disease.
J Crohns Colitis. 2017 Jul 1;11(7):831-839. doi: 10.1093/ecco-jcc/jjx012.
5
Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum.
ISME J. 2007 Sep;1(5):403-18. doi: 10.1038/ismej.2007.52. Epub 2007 Jul 12.
6
Characterization of T-cell Receptor Repertoire in Inflamed Tissues of Patients with Crohn's Disease Through Deep Sequencing.
Inflamm Bowel Dis. 2016 Jun;22(6):1275-85. doi: 10.1097/MIB.0000000000000752.
7
Mucosal healing of ileal lesions is associated with long-term clinical remission after infliximab maintenance treatment in patients with Crohn's disease.
Dig Endosc. 2015 Jan;27(1):73-81. doi: 10.1111/den.12313. Epub 2014 Jul 17.
8
An ileal Crohn's disease gene signature based on whole human genome expression profiles of disease unaffected ileal mucosal biopsies.
PLoS One. 2012;7(5):e37139. doi: 10.1371/journal.pone.0037139. Epub 2012 May 14.
9
Glucocorticoid treatment in ileal Crohn's disease: relief of symptoms but not of endoscopically viewed inflammation.
Gut. 1990 Mar;31(3):325-8. doi: 10.1136/gut.31.3.325.
10
CD28+ intraepithelial lymphocytes with long telomeres are recruited within the inflamed ileal mucosa in Crohn disease.
Hum Immunol. 2001 Jul;62(7):694-700. doi: 10.1016/s0198-8859(01)00258-0.
引用本文的文献
1
LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model.
J Neuroinflammation. 2025 Jul 5;22(1):174. doi: 10.1186/s12974-025-03502-7.
2
Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn's disease.
Nat Commun. 2024 Aug 22;15(1):7204. doi: 10.1038/s41467-024-51580-7.
3
Single cell transcriptomic analysis of the canine duodenum in chronic inflammatory enteropathy and health.
Front Immunol. 2024 Jun 12;15:1397590. doi: 10.3389/fimmu.2024.1397590. eCollection 2024.
4
Identification of master regulator genes controlling pathogenic CD4 T cell fate in inflammatory bowel disease through transcriptional network analysis.
Sci Rep. 2024 May 8;14(1):10553. doi: 10.1038/s41598-024-61158-4.
5
Single-cell transcriptomics reveals activation of endothelial cell and identifies LHPP as a potential target in ulcerative colitis.
Heliyon. 2024 Apr 3;10(7):e29163. doi: 10.1016/j.heliyon.2024.e29163. eCollection 2024 Apr 15.
6
Single-cell analysis identifies phospholysine phosphohistidine inorganic pyrophosphate phosphatase as a target in ulcerative colitis.
World J Gastroenterol. 2023 Dec 28;29(48):6222-6234. doi: 10.3748/wjg.v29.i48.6222.
7
Deciphering the different phases of preclinical inflammatory bowel disease.
Nat Rev Gastroenterol Hepatol. 2024 Feb;21(2):86-100. doi: 10.1038/s41575-023-00854-4. Epub 2023 Nov 10.
8
A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn's Disease.
bioRxiv. 2023 Oct 2:2023.09.30.560293. doi: 10.1101/2023.09.30.560293.
9
A Roadmap for the Human Gut Cell Atlas.
Nat Rev Gastroenterol Hepatol. 2023 Sep;20(9):597-614. doi: 10.1038/s41575-023-00784-1. Epub 2023 May 31.
10
The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis.
Cell Rep Med. 2023 May 16;4(5):101038. doi: 10.1016/j.xcrm.2023.101038. Epub 2023 May 8.
本文引用的文献
1
The Human Cell Atlas.
Elife. 2017 Dec 5;6:e27041. doi: 10.7554/eLife.27041.
2
Massively parallel digital transcriptional profiling of single cells.
Nat Commun. 2017 Jan 16;8:14049. doi: 10.1038/ncomms14049.
3
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Nat Genet. 2015 Sep;47(9):979-986. doi: 10.1038/ng.3359. Epub 2015 Jul 20.
4
Genetic and epigenetic fine mapping of causal autoimmune disease variants.
Nature. 2015 Feb 19;518(7539):337-43. doi: 10.1038/nature13835. Epub 2014 Oct 29.
5
Generation of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated disease.
Gut. 2015 Feb;64(2):250-9. doi: 10.1136/gutjnl-2013-306657. Epub 2014 May 5.
Zotero 插件