Dean B S, Krenzelok E P
J Toxicol Clin Toxicol. 1987;25(3):221-30. doi: 10.3109/15563658708992626.
The accidental ingestion of iron-containing preparations is relatively common in children, as are intentional overdoses with iron in adults. One of the most commonly used treatment modalities is the use of orally administered sodium bicarbonate or sodium hydrogen phosphate, which is thought to render iron less soluble and bioavailable by converting it to ferrous carbonate or ferrous phosphate. An in vivo parallel study utilizing 3 groups of 50 male Sprague-Dawley rats was designed to evaluate the effectiveness of oral complexation agents at five distinct time points. Each animal group was dosed with 300 mg/kg ferrous sulfate (60 mg/kg elemental iron), followed by a 5% solution of either sodium bicarbonate, sodium dihydrogen phosphate, or a control of distilled water. The animals were anesthetized in each group at separate time points of 0, 1, 2, 4, and 6 hours post iron load, and blood samples were taken to determine serum iron levels. There were no differences in serum iron levels between the control group and either complexing agent. This suggests that oral complexation in iron poisoning may be ineffective.
含铁制剂的意外摄入在儿童中较为常见，而成人故意过量服用铁剂的情况也不少见。最常用的治疗方法之一是口服碳酸氢钠或磷酸二氢钠，人们认为这两种物质通过将铁转化为碳酸亚铁或磷酸亚铁，使铁的溶解度和生物利用度降低。一项体内平行研究使用了三组，每组50只雄性斯普拉格-道利大鼠，旨在评估口服络合剂在五个不同时间点的有效性。每组动物均给予300 mg/kg硫酸亚铁（60 mg/kg元素铁），随后分别给予5%的碳酸氢钠溶液、磷酸二氢钠溶液或蒸馏水作为对照。在铁负荷后的0、1、2、4和6小时的不同时间点对每组动物进行麻醉，并采集血样以测定血清铁水平。对照组与任何一种络合剂组之间的血清铁水平均无差异。这表明铁中毒时口服络合治疗可能无效。
