Qian Hai, Wang Long, Brooks Kenneth Scott, Zhao Xiaochun, Shi Xiang'en, Lei Ting
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, People's Republic of China.
University of Arizona College of Medicine, Tucson, Arizona, USA.
World Neurosurg. 2019 Feb;122:195. doi: 10.1016/j.wneu.2018.10.167. Epub 2018 Nov 2.
Mycotic aneurysm, also referred to as infected aneurysm, is a rare entity that may result from the bacterial infection or infective endocarditis. The treatment options include conservative medication and endovascular or direct microsurgical intervention. However, the optimal strategy remains unknown and cerebral revascularization may be required in some rare cases. In this surgical video, we demonstrate a distal middle cerebral artery (MCA) mycotic aneurysm that we treated by intracranial-intracranial bypass with an interpositional graft. Our patient is a 53-year-old male who presented with a 6-day history of severe headache. He was subsequently admitted to our institution. Preoperative computed tomography angiography showed a left temporal hematoma (>30 mL) and an opercular segment of the MCA (M3) aneurysm, which was highly suspicious for mycotic origin. A standard frontotemporal craniotomy was carried out with preservation of superficial temporal artery (STA). Following the sylvian fissure dissection, the aneurysm was exposed with the characteristics of a thick wall and an undefinable neck, which made direct clip application difficult. The aneurysm was resected initially, and 2 cut ends were reconnected by an STA graft. Following arterial reconstruction, intraoperative Doppler revealed a patent status of the interpositional graft vessel. Postoperatively, no neurologic deficit was observed and computed tomography angiography demonstrated total elimination of the aneurysm without stenosis of the graft vessel. Low-molecular dextran was prescribed rather than aspirin, as there was concern for hemorrhage. Antibiotic treatment was used for at least 4 weeks, and the patient was transferred to the inpatient cardiology team for management of endocarditis. A 4-month follow-up angiogram showed a patent STA and excellent left distal MCA blood flow (Video 1). The favorable outcome of this case revealed that MCA-to-MCA bypass with interpositional graft is a safe, effective method for the unclippable cerebral aneurysm. As other authors have asserted, a full dose of long-term antibiotic therapy remains essential following intervention. Meanwhile, dextran has proved to be a viable alternative for anticoagulation during perioperative management of bypass surgery..
真菌性动脉瘤,也被称为感染性动脉瘤,是一种罕见的病症,可能由细菌感染或感染性心内膜炎引起。治疗选择包括保守药物治疗以及血管内或直接显微手术干预。然而,最佳策略仍不明确,在某些罕见情况下可能需要进行脑血运重建。在本手术视频中,我们展示了一例通过颅内-颅内搭桥并使用间置移植物治疗的大脑中动脉(MCA)远端真菌性动脉瘤。我们的患者是一名53岁男性,有6天严重头痛病史。随后他被收治入我院。术前计算机断层扫描血管造影显示左侧颞叶血肿(>30 mL)以及MCA的岛叶段(M3)动脉瘤,高度怀疑为真菌性起源。进行了标准的额颞开颅手术,保留了颞浅动脉(STA)。在解剖外侧裂后,暴露了动脉瘤,其具有厚壁和难以明确的瘤颈的特征,这使得直接夹闭操作困难。最初切除了动脉瘤,两个断端通过STA移植物重新连接。动脉重建后,术中多普勒显示间置移植物血管通畅。术后,未观察到神经功能缺损,计算机断层扫描血管造影显示动脉瘤完全消失,移植物血管无狭窄。由于担心出血,开具了低分子右旋糖酐而非阿司匹林。使用抗生素治疗至少4周,患者被转至住院心脏病学团队进行感染性心内膜炎的管理。4个月的随访血管造影显示STA通畅,左侧MCA远端血流良好(视频1)。该病例的良好结果表明,使用间置移植物进行MCA-to-MCA搭桥是治疗无法夹闭的脑动脉瘤的一种安全、有效的方法。正如其他作者所主张的,干预后全剂量的长期抗生素治疗仍然至关重要。同时,右旋糖酐已被证明是旁路手术围手术期管理中抗凝的一种可行替代方法。