假性剥脱性青光眼患者视网膜静脉阻塞的发病率：一项回顾性队列研究。
The Incidence of Retinal Vein Occlusion in Patients with Pseudoexfoliation Glaucoma: A Retrospective Cohort Study.
作者信息
Antman Gal, Keren Shay, Kurtz Shimon, Rosenblatt Amir, Rachmiel Rony
机构信息
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel,
出版信息
Ophthalmologica. 2019;241(3):130-136. doi: 10.1159/000492401. Epub 2018 Nov 2.
PURPOSE
The aim of this study was to evaluate pseudoexfoliation (PXF) as an independent risk factor for the occurrence of retinal vein occlusion (RVO).
METHODS
This is a retrospective cohort study on the records of 300 PXF glaucoma patients (PXF group), 300 non-PXF glaucoma patients, and 599 nonglaucoma non-PXF (nGnP group) patients.
RESULTS
Multivariate analysis resulted in a significant probability for RVO in the PXF (p = 0.005; OR 2.29 [1.13-4.68]) and non-PXF glaucoma groups (p = 0.005; OR 3.03 [1.55-5.94]) compared to the nGnP group. There was a much higher probability for central RVO (CRVO) in the PXF (p = 0.013; OR 3.64 [1.39-9.49]) and non-PXF glaucoma groups (p = 0.013; OR 3.78 [1.48-9.65]) compared to the nGnP group. After matching and excluding neovascular glaucoma, no significant difference was found between the PXF and non-PXF glaucoma groups regarding RVO (p = 0.541), CRVO (p = 0.092), and branch RVO (p = 0.774).
CONCLUSIONS
PXF and other types of glaucoma are associated with RVOs, mainly CRVO. PXF was not found to be an independent risk factor for CRVO.
目的
本研究旨在评估假性剥脱综合征（PXF）作为视网膜静脉阻塞（RVO）发生的独立危险因素。
方法
这是一项回顾性队列研究，纳入了300例PXF青光眼患者（PXF组）、300例非PXF青光眼患者和599例非青光眼非PXF患者（nGnP组）的记录。
结果
多因素分析显示，与nGnP组相比，PXF组（p = 0.005；OR 2.29 [1.13 - 4.68]）和非PXF青光眼组发生RVO的概率显著增加（p = 0.005；OR 3.03 [1.55 - 5.94]）。与nGnP组相比，PXF组（p = 0.013；OR 3.64 [1.39 - 9.49]）和非PXF青光眼组发生中心性视网膜静脉阻塞（CRVO）的概率更高（p = 0.013；OR 3.78 [1.48 - 9.65]）。在匹配并排除新生血管性青光眼后，PXF组和非PXF青光眼组在RVO（p = 0.541）、CRVO（p = 0.092）和分支视网膜静脉阻塞（p = 0.77）方面未发现显著差异。
结论
PXF和其他类型的青光眼与RVO相关，主要是CRVO。未发现PXF是CRVO的独立危险因素。
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