Zhang L, Wang X, Zhang Y, Yang Y F, Li W W, Li B L, Zhang D, Lü L X
The Second Affiliated Hospital of Xinxiang Medical University, Henan Key Lab of Biological Psychiatry of Xinxiang Medical University, Xinxiang 453002, China.
Zhonghua Yi Xue Za Zhi. 2018 Oct 9;98(37):2968-2972. doi: 10.3760/cma.j.issn.0376-2491.2018.37.003.
To investigate the gray matter(GM) volume and the change of GM volume after antipsychotic treatment for 8 weeks in first-episode drug-naive adolescents with schizophrenia. T1-weighted brain MRIs were obtained on a 3T scanner in 35 controls and 35 subjects with adolescents schizophrenia who were admitted to the Second Affiliated Hospital of Xinxiang Medical College from April 2015 to June 2016 and not given antipsychotic medication, the schizophrenia patients received second scan after 8 weeks of antipsychotic treatment. Positive and negative syndrome scale (PANSS) assessments were performed in patients pre- and post-treatment; voxel-based morphometry (VBM) was used to analyze changes of GM volume and the correlation between the baseline GM volume and the PANSS scores was further analyzed. GM volumes in the left frontal gyrus (MIN(x, y, z): -13.5, 36, 46.5), left superior parietal lobule (MIN(x, y, z): -52.5, -42, 52.5), left inferior parietal lobule (MIN(x, y, z): -31.5, -45, 69) and left central anterior (MIN(x, y, z): 9, 21, 61.5) were significantly smaller than those in the normal control group (=-4.384 0, -4.556 2, -6.430 9, -4.313 9 respectively, <0.001); after treatment for 8 weeks PANSS scores were significantly lower than those of baseline (<0.001), however, there was no significant difference in regional GM volume between the pre-and post-treatment (>0.05) and no significant correlation was found between GM volume and PANSS scores. There are local GM volume reductions in subjects with adolescents schizophrenia and these regions may be independent to mental symptoms of patients.
为研究首发未用药青少年精神分裂症患者的灰质（GM）体积及抗精神病药物治疗8周后GM体积的变化。于2015年4月至2016年6月在新乡医学院第二附属医院，对35名对照者和35名青少年精神分裂症患者进行3T扫描仪T1加权脑MRI检查，这些精神分裂症患者未接受过抗精神病药物治疗，在接受抗精神病药物治疗8周后进行第二次扫描。对患者治疗前后进行阳性与阴性症状量表（PANSS）评估；采用基于体素的形态学测量（VBM）分析GM体积变化，并进一步分析基线GM体积与PANSS评分之间的相关性。左侧额回（MIN(x, y, z): -13.5, 36, 46.5）、左侧顶上小叶（MIN(x, y, z): -52.5, -42, 52.5）、左侧顶下小叶（MIN(x, y, z): -31.5, -45, 69）和左侧中央前回（MIN(x, y, z): 9, 21, 61.5）的GM体积显著小于正常对照组（分别为=-4.384 0、-4.556 2、-6.430 9、-4.313 9，<0.001）；治疗8周后PANSS评分显著低于基线水平（<0.001），然而，治疗前后各区域GM体积无显著差异（>0.05），GM体积与PANSS评分之间无显著相关性。青少年精神分裂症患者存在局部GM体积减少，且这些区域可能与患者精神症状无关。
