Qiu Z H, Wei Q S, Wu Y X, Luo Y M, Luo Y M
The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, Guangzhou 510120, China.
Zhonghua Yi Xue Za Zhi. 2018 Oct 30;98(40):3244-3248. doi: 10.3760/cma.j.issn.0376-2491.2018.40.006.
To investigate the efficacy of simple device of continuous positive airway pressure (CPAP) in the treatment of obstructive sleep apnea (OSA). A double-blind study was performed on 53 OSA patients who received overnight simple CPAP and traditional CPAP in a random order during polysomnography. Pressure for CPAP treatment was manual titrated. The sleep apnea hypopnea index (AHI), arousal index (ArI), Oxygen desaturation Index (ODI), sleep structure and the preference for CPAP devices of the patients were observed. AHI, ArI, ODI decreased significantly from 35.7 (18.1, 58.8)/h, (29.4±18.6)/h, 22.0 (13.9, 47.3)/h before treatment to 1.7 (0.7, 4.4)/h, (11.5±5.1) /h and 1.3 (0.4, 3.6)/h after treatment with simple CPAP, respectively (all <0.05). There was no statistically significant difference in residual AHI [1.7 (0.7, 4.4)/h vs 1.9 (0.8, 4.3)/h], ArI [(11.5±5.1)/h vs (10.5±4.4)/h] and ODI [1.3 (0.4, 3.6)/h vs 1.3 (0.5, 4.2)/h] between treatment with simple CPAP and traditional CPAP (all >0.05). The amount of time spent on deep sleep (stage Ⅲ) and rapid eye movement (REM) increased significantly from (6.2+ 6.6)% and (16.3+ 7.0)% before treatment to (11.7±8.5)% and (20.7±5.1)% during treatment with simple CPAP and (11.4±8.6)% and (20.9±5.0)% with traditional CPAP, respectively. The patients had no clear preference for two CPAP devices. Traditional CPAP can be replaced by the simple CPAP to treat patients with OSA.
探讨简易持续气道正压通气（CPAP）装置治疗阻塞性睡眠呼吸暂停（OSA）的疗效。对53例OSA患者进行双盲研究，在多导睡眠监测期间，患者随机顺序接受夜间简易CPAP和传统CPAP治疗。CPAP治疗压力采用人工滴定。观察患者的睡眠呼吸暂停低通气指数（AHI）、觉醒指数（ArI）、氧饱和度下降指数（ODI）、睡眠结构以及对CPAP装置的偏好。简易CPAP治疗前AHI、ArI、ODI分别为35.7（18.1，58.8）次/小时、（29.4±18.6）次/小时、22.0（13.9，47.3）次/小时，治疗后分别降至1.7（0.7，4.4）次/小时、（11.5±5.1）次/小时和1.3（0.4，3.6）次/小时（均P<0.05）。简易CPAP与传统CPAP治疗后残余AHI[1.7（0.7，4.4）次/小时对1.9（0.8，4.3）次/小时]、ArI[（11.5±5.1）次/小时对（10.5±4.4）次/小时]和ODI[1.3（0.4，3.6）次/小时对1.3（0.5，4.2）次/小时]差异均无统计学意义（均P>0.05）。简易CPAP治疗期间深睡眠（Ⅲ期）和快速眼动（REM）睡眠时间占比分别从治疗前的（6.2±6.6）%和（16.3±7.0）%显著增加至（11.7±8.5）%和（20.7±5.1）%，传统CPAP治疗期间分别为（11.4±8.6）%和（20.9±5.0）%。患者对两种CPAP装置无明显偏好。传统CPAP可被简易CPAP替代用于治疗OSA患者。
