Jiao D C, Qiao J H, Zhu J J, Wang L N, Ma Y Z, Lu Z D, Liu Z Z
Department of Breast Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China.
Zhonghua Yi Xue Za Zhi. 2018 Oct 30;98(40):3258-3262. doi: 10.3760/cma.j.issn.0376-2491.2018.40.009.
To investigate the predictors of axillary lymph node metastasis and the breast cancer-specific survival (BCSS) in patients with T1 breast cancer. A retrospective analysis of clinical and pathological data of 840 T1 invasive breast cancer cases between January 2009 and January 2014 in Henan Cancer Hospital was conducted.Chi square test and Logistic regression analysis were carried out to identify relevant factors of lymph node metastasis. Analysis of prognostic factors were analyzed by Log-rank test and Cox regression. Among the 840 T1 breast cancer cases, positive axillary lymph nodes were found in 150 (17.9%) cases. Univariate analysis showed that tumor size, histological grade, tumor location, and HER2 status were associated with axillary lymph node status (<0.05). Multivariate analysis showed that tumor size, histological grade, tumor location, and HER2 status were independent predictive factors of axillary lymph node metastasis (<0.05). Log-rank test showed that tumor size, histological grade, HER2 status, partial response (PR) status and number of positive lymph nodes were important factors influencing BCSS of the patients with positive axillary lymph nodes (<0.05). Cox analysis showed that the size of the primary tumors and the number of positive lymph nodes were independent factors affecting the BCSS of the patients(<0.05). Tumor size, histological grade, tumor location and HER2 status correlated with axillary lymph nodes status of T1 breast cancer. For T1 breast cancer patients with positive axillary lymph node, more positive lymph nodes involved and smaller primary tumor correlated with worse prognosis.
探讨T1期乳腺癌患者腋窝淋巴结转移及乳腺癌特异性生存（BCSS）的预测因素。对河南省肿瘤医院2009年1月至2014年1月期间840例T1期浸润性乳腺癌病例的临床和病理资料进行回顾性分析。采用卡方检验和Logistic回归分析确定淋巴结转移的相关因素。通过Log-rank检验和Cox回归分析预后因素。在840例T1期乳腺癌病例中，150例（17.9%）发现腋窝淋巴结阳性。单因素分析显示，肿瘤大小、组织学分级、肿瘤位置和HER2状态与腋窝淋巴结状态相关（<0.05）。多因素分析显示，肿瘤大小、组织学分级、肿瘤位置和HER2状态是腋窝淋巴结转移的独立预测因素（<0.05）。Log-rank检验显示，肿瘤大小、组织学分级、HER2状态、部分缓解（PR）状态和阳性淋巴结数量是影响腋窝淋巴结阳性患者BCSS的重要因素（<0.05）。Cox分析显示，原发肿瘤大小和阳性淋巴结数量是影响患者BCSS的独立因素（<0.05）。肿瘤大小、组织学分级、肿瘤位置和HER2状态与T1期乳腺癌腋窝淋巴结状态相关。对于腋窝淋巴结阳性的T1期乳腺癌患者，阳性淋巴结累及越多且原发肿瘤越小，预后越差。
