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用于深部原位脑胶质瘤光声成像的高灵敏度钼-吲哚菁绿杂交体

Highly Sensitive MoS-Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site.

作者信息

Liu Chengbo, Chen Jingqin, Zhu Ying, Gong Xiaojing, Zheng Rongqin, Chen Ningbo, Chen Dong, Yan Huixiang, Zhang Peng, Zheng Hairong, Sheng Zonghai, Song Liang

机构信息

Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, People's Republic of China.

Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, 518055, People's Republic of China.

出版信息

Nanomicro Lett. 2018;10(3):48. doi: 10.1007/s40820-018-0202-8. Epub 2018 Apr 23.

DOI:10.1007/s40820-018-0202-8
PMID:30393697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6199097/
Abstract

Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS-ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS-ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS-ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine.

摘要

光声技术与分子成像相结合是一种准确诊断脑胶质瘤的高效方法。对于更深部位的胶质瘤检测，需要具有更高光声成像灵敏度的造影剂。在此，我们报道了一种将吲哚菁绿（ICG）共轭到二硫化钼（MoS）纳米片表面的MoS-ICG杂化物。与MoS纳米片相比，该杂化物显著提高了光声成像灵敏度。这种共轭作用导致在宽近红外光谱范围内具有非常高的光吸收率、ICG吸收峰的红移以及ICG光热/光声转换效率的提高。使用MoS-ICG作为原位胶质瘤体内光声成像的造影剂，可清晰地观察到小鼠头皮下3.5毫米的肿瘤块，这比我们之前报道的使用MoS纳米片成像的肿瘤深了近两倍。因此，结合其良好的稳定性和高生物相容性，本研究中开发的MoS-ICG杂化物在转化医学中的高效肿瘤分子成像方面具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/a8063ef3c976/40820_2018_202_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/6e98195fd718/40820_2018_202_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/6e2d55af7044/40820_2018_202_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/15a430e6d453/40820_2018_202_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/afd7e6e5f6ed/40820_2018_202_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/731dbc165a4f/40820_2018_202_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/a7bf043893fa/40820_2018_202_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/a8063ef3c976/40820_2018_202_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/6e98195fd718/40820_2018_202_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/6e2d55af7044/40820_2018_202_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/15a430e6d453/40820_2018_202_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/afd7e6e5f6ed/40820_2018_202_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/731dbc165a4f/40820_2018_202_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/a7bf043893fa/40820_2018_202_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2772/7747392/a8063ef3c976/40820_2018_202_Fig6_HTML.jpg

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