Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS, 39216, United States.
Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS, 39216, United States; Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, 1500 E Woodrow Wilson Ave, Jackson, MS, 39216, United States.
Pharmacol Res. 2018 Nov;137:252-258. doi: 10.1016/j.phrs.2018.10.026. Epub 2018 Oct 28.
Following myocardial infarction (MI), timely resolution of inflammation promotes wound healing and scar formation while limiting excessive tissue damage. Resolution promoting factors (RPFs) are agents that blunt leukocyte trafficking and inflammation, promote necrotic and apoptotic cell clearance, and stimulate scar formation. Previously identified RPFs include mediators derived from lipids (resolvins, lipoxins, protectins, and maresins), proteins (glucocorticoids, annexin A1, galectin 1, and melanocortins), or gases (CO, HS, and NO). Matrix metalloproteinase-12 (MMP-12; macrophage elastase) has shown promising RPF qualities in a variety of disease states. We review here the evidence that MMP-12 may serve as a novel RPF with potential therapeutic efficacy in the setting of MI.
心肌梗死后(MI),炎症的及时消退可促进伤口愈合和瘢痕形成,同时限制过度的组织损伤。促消退因子(RPFs)是一种能够抑制白细胞迁移和炎症反应、促进坏死和凋亡细胞清除以及刺激瘢痕形成的药物。先前已经鉴定出的 RPFs 包括来自脂质(消退素、脂氧素、保护素和maresins)、蛋白质(糖皮质激素、膜联蛋白 A1、半乳糖凝集素 1 和黑色素皮质素)或气体(CO、HS 和 NO)的介质。基质金属蛋白酶-12(MMP-12;巨噬细胞弹性蛋白酶)在多种疾病状态下显示出有前景的 RPF 特性。在这里,我们回顾了 MMP-12 可能作为一种新型 RPF 的证据,其在 MI 中的治疗效果具有潜在的应用价值。