Mirimanoff R O, Choi N C
Oncology. 1987;44(4):232-6. doi: 10.1159/000226484.
Intradural spinal metastases (ISM) are rare and primarily found associated with certain types of brain tumors like medulloblastoma. Their association with metastases to the brain has been recently described and seems to occur more frequently in posterior fossa lesions. We reviewed patients treated at Massachusetts General Hospital for posterior fossa brain metastases from various primary cancers, and evaluated the risk of concomitant or subsequent ISM. Of 104 patients, 10 developed ISM, with a 1-year actuarial risk of 25%. The risk was not significantly related to age, sex, histology, site of primary tumor or previous therapy. The study suggests that in patients with posterior fossa metastasis, particular attention should be paid to seeding via cerebrospinal fluid and drop metastases to the spinal cord.
硬脊膜内脊髓转移瘤（ISM）较为罕见，主要见于某些类型的脑肿瘤，如髓母细胞瘤。近期已有关于其与脑转移瘤相关性的描述，且似乎在后颅窝病变中更常发生。我们回顾了在马萨诸塞州总医院接受治疗的因各种原发性癌症发生后颅窝脑转移瘤的患者，并评估了并发或随后发生ISM的风险。在104例患者中，有10例发生了ISM，1年精算风险为25%。该风险与年龄、性别、组织学类型、原发肿瘤部位或既往治疗无显著相关性。该研究提示，对于后颅窝转移瘤患者，应特别关注脑脊液播散和脊髓的滴状转移。
