Hicks Jill, Platt Simon, Stewart Georgina, Senneca Christine, Holmes Shannon, Kent Marc, Howerth Elizabeth, Kaplan Jared, Kaplan Edward
Veterinary Teaching Hospital, University of Georgia, Athens, Georgia, USA.
Small Animal Hospital, University of Florida, Gainesville, FL, USA.
Vet Med Sci. 2019 Feb;5(1):5-18. doi: 10.1002/vms3.124. Epub 2018 Nov 5.
Entotherapy an image-guided drug-eluting microcylinder platform, has the potential to bypass the limitations of systemic chemotherapy use in the treatment of canine brain tumours. Gliomas, which are common in dogs and also represent the majority of fatal brain tumours in humans, can be amenable to chemotherapy with temozolomide. Biopolymer microcylinders conjugated with temozolomide and gadolinium were implanted into partially resected tumours of four client-owned dogs with gliomas. All four dogs presented with generalized seizures and had mild to no neurologic deficits at the time of craniotomy. All dogs underwent craniotomy for implantation of the microcylinders into partially resected gliomas (glioblastoma multiforme {n = 1} or oligodendroglioma {n = 3}). All dogs recovered well from the craniotomy and implantation procedure. This novel procedure appears to be feasible and tolerated in tumour-bearing dogs. A future controlled clinical study can now aim to evaluate the microcylinder implantation for long-term efficacy.
肠内疗法是一种图像引导的药物洗脱微圆柱体平台，有潜力克服全身化疗在犬类脑肿瘤治疗中的局限性。胶质瘤在犬类中很常见，在人类致命性脑肿瘤中也占大多数，可采用替莫唑胺进行化疗。将与替莫唑胺和钆结合的生物聚合物微圆柱体植入四只患有胶质瘤的客户拥有犬的部分切除肿瘤中。所有四只犬均出现全身性癫痫发作，开颅手术时神经功能缺损轻微或无。所有犬均接受开颅手术，将微圆柱体植入部分切除的胶质瘤（多形性胶质母细胞瘤{n = 1}或少突胶质细胞瘤{n = 3}）中。所有犬开颅手术及植入术后恢复良好。这种新方法在患肿瘤犬中似乎可行且耐受性良好。现在一项未来的对照临床研究可以旨在评估微圆柱体植入的长期疗效。
