From the Departments of Nuclear Medicine.
Gastroenterology, and.
Clin Nucl Med. 2019 Jan;44(1):70-71. doi: 10.1097/RLU.0000000000002369.
An 81-year-old man with a large hepatocellular carcinoma was referred in our institution for Y radioembolization (RE). The preliminary arteriography using Tc-macroaggregate albumin demonstrated an important hepatopulmonary shunt. It was an exclusion criterion for RE due to high risks of lung radiations. Then, the patient was treated with sorafenib during 4 months, stopped because of grade 3 toxicity. A second liver arteriography was performed, and Tc-macroaggregate albumin imaging showed an important reduction of the lung shunt. Transient therapy with sorafenib permitted to close the lung shunt and was a bridge for RE.
一位 81 岁男性患有大肝癌，被转介至我院进行 Y 放射性栓塞 (RE)。使用 Tc-巨聚合白蛋白进行初步动脉造影显示存在重要的肝肺分流。由于存在高肺部辐射风险，这是 RE 的排除标准。随后，患者接受索拉非尼治疗 4 个月，因 3 级毒性而停药。进行了第二次肝动脉造影，Tc-巨聚合白蛋白成像显示肺分流明显减少。短暂的索拉非尼治疗能够关闭肺分流，并为 RE 提供了桥梁。
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