子宫内膜自噬在生理和病理生理过程中的作用
Role of Endometrial Autophagy in Physiological and Pathophysiological Processes.
作者信息
Yang Shaoliang, Wang Haiyan, Li Dajin, Li Mingqing
机构信息
NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University, 200080, People's Republic of China.
Department of Gynecology of Integrated Traditional Chinese and Western Medicine, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, 200011, People's Republic of China.
出版信息
J Cancer. 2019 Jun 9;10(15):3459-3471. doi: 10.7150/jca.31742. eCollection 2019.
Endometrium is the mucosal lining of the uterus which expressed a cyclic process of proliferation, secretion and scaling under the control of hormones secreted by the ovary, and it also plays an indispensable role in the embryo implantation, the constitution of fetal-maternal interface, and the maintaining of pregnancy. In pathophysiological conditions, the abnormality or disorder of endometrium may lead to endometrium-related diseases, such as endometriosis, endometrium hyperplasia and even endometrial carcinoma. In recent years, more and more evidence revealed that autophagy exists in both the endometrium stroma cells and epithelial cells, and the activity of autophagy is changed in the different phases of menstruation, as well as in the endometrium-related diseases. Here, we aim to review the activity level, the regulatory factors and the function of autophagy in physiological and pathophysiological endometria, and to discuss the potential value of autophagy as a target for therapies of endometrium-related diseases.
子宫内膜是子宫的黏膜层，在卵巢分泌的激素控制下呈现增殖、分泌和脱落的周期性过程，并且在胚胎着床、母胎界面的构成以及维持妊娠方面发挥不可或缺的作用。在病理生理状况下，子宫内膜的异常或紊乱可能导致子宫内膜相关疾病，如子宫内膜异位症、子宫内膜增生甚至子宫内膜癌。近年来，越来越多的证据表明自噬存在于子宫内膜基质细胞和上皮细胞中，并且自噬活性在月经的不同阶段以及子宫内膜相关疾病中发生改变。在此，我们旨在综述自噬在生理和病理生理状态下子宫内膜中的活性水平、调控因子及功能，并探讨自噬作为子宫内膜相关疾病治疗靶点的潜在价值。
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