DʼOnofrio Augusto, Bagozzi Lorenzo, Tessari Chiara, Francescato Annalisa, Cibin Giorgia, Besola Laura, Pesce Rita, Toscano Giuseppe, Gerosa Gino
From the Division of Cardiac Surgery, University of Padova, Padova, Italy.
Innovations (Phila). 2018 Sep/Oct;13(5):356-360. doi: 10.1097/IMI.0000000000000558.
The aim of this retrospective, single-center study was to evaluate the occurrence of conduction disorders after rapid deployment aortic bioprosthesis implantation.
Electrocardiograms of patients undergoing INTUITY (Edwards Lifesciences, Irvine, CA USA) bioprosthesis implantation were collected at admission, during postoperative course, and at discharge. Primary end point was the occurrence of new-onset conduction disorders, defined as complete left bundle branch block, complete right bundle branch block, permanent pacemaker implantation, and worsening of pre-existing rhythm abnormalities. Secondary end points were the assessment of preoperative and postoperative QRS duration and the identification of transitory conduction disorders.
Forty-four patients (July 2015-December 2016) were included in the analysis. Preoperatively, patients with normal conduction and with already existing disorders were 25 (56.8%) and 19 (43.2%), respectively. Primary end point occurred in 14 patients (31.8%). Two patients (4.5%) received pacemaker implantation. In patients with normal preoperative conduction, new abnormalities were found in eight cases (32%): all left bundle branch blocks with one pacemaker implantation. Worsening of pre-existing conduction disorders was found in six patients (31.6%) with one pacemaker implantation. QRS duration increased in 20 patients (45.4%), and average increase was 37 milliseconds. Overall, we observed a significant increase of QRS (96 ± 21 milliseconds vs. 111 ± 28 milliseconds, P < 0.001). Three patients experienced a new-onset temporary left bundle branch block.
New-onset conduction disorders or worsening of pre-existing rhythm abnormalities occur in one third of patients after rapid deployment aortic bioprosthesis implantation. Although the incidence of postoperative pacemaker implantation before discharge is low, strict follow-up is mandatory to identify a potential need for pacemaker implantation in a timely manner.
本回顾性单中心研究旨在评估快速释放主动脉生物假体植入术后传导障碍的发生情况。
收集接受INTUITY(美国爱德华生命科学公司,加利福尼亚州欧文市)生物假体植入患者入院时、术后病程中及出院时的心电图。主要终点是新发传导障碍的发生,定义为完全性左束支传导阻滞、完全性右束支传导阻滞、永久性起搏器植入以及既往存在的节律异常加重。次要终点是评估术前和术后QRS时限以及识别短暂性传导障碍。
44例患者(2015年7月至2016年12月)纳入分析。术前传导正常和已有传导障碍的患者分别为25例(56.8%)和19例(43.2%)。14例患者(31.8%)出现主要终点事件。2例患者(4.5%)接受了起搏器植入。术前传导正常的患者中,8例(32%)发现新的异常:均为左束支传导阻滞且1例植入起搏器。6例患者(31.6%)既往存在的传导障碍加重且1例植入起搏器。20例患者(45.4%)QRS时限增加,平均增加37毫秒。总体而言,我们观察到QRS显著增宽(96±21毫秒对111±28毫秒,P<0.001)。3例患者出现新发短暂性左束支传导阻滞。
快速释放主动脉生物假体植入术后三分之一的患者出现新发传导障碍或既往存在的节律异常加重。尽管出院前术后起搏器植入的发生率较低,但必须进行严格随访以便及时发现潜在的起搏器植入需求。